Aromatase inhibitors (AI) are often used as hormone therapy drugs to slow down or pause the enlargement of hormone receptor-positive tumours among postmenopausal women. These inhibitors block aromatase enzyme, thus reducing body estrogen levels and inhibiting the cancer growth. Yhe most common side effects associated with their use are bone loss, increased risk of fractures and osteoporosis.
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A recent study published in Hormone Molecular Biology and Clinical Investigation suggests that exercise may help minimise the backache during pregnancy. This prospective control study assessed the efficacy of an exercise program in reducing back pain in pregnant women.
7min read
Recent study affirms Adhesive Dermally-Applied Microarray (ADAM) of Zolmitriptan showed promising efficacy and pharamcokinetic profile for migraine treatment. ADAM is an intracutaneous drug administration device which provides intracutaneous delivery of Zolmitriptan and thus providing more rapid absorption than orally administered triptans.
7min read
A recently published study in the 'PLOS one journal' deduced that the alteration in the proximal and distal muscle activity might negatively affect the postural control and quality of movement, which may initiate prolonged functional impairments. Therefore, doing hip and ankle muscle exercises in the rehabilitation of ankle instability might be beneficial for these patients.
8min read
According to a recent study by Archives of Orthopaedic and Trauma Surgery, the hip arthroscopy presents better outcomes even 11 years after hip arthroscopy as no significant progression of osteoarthritis noticed on plain radiography. Hip arthroplasty (HP) is used to treat hip osteoarthritis for many years. The evidence of HP advantages after one year among patients with femoroacetabular impingement (FAI) is well understood, but long-term evidence on patient-reported outcomes (PROMs) and osteoarthritis progression was insufficient. The present study was conducted to evaluate the long-term radiological and clinical findings 11 years after the HA.
7min read
Key Take-Away:
Migraine is a chronic, prevalent, and multifactorial neurovascular disorder that leads to severe functional disability. Galcanezumab is an effective medication that can prevent the development of migraine and the study validate the Galcanezumab impact among episodic migraineurs by diagnosing the changes in two disease-specific patient-reported outcomes after 12-week treatment.
Introduction
Headache‐associated functional impairment management is a primary goal for PROs and migraine preventive treatment. Recognizing which medications can enhance patient functioning along with managing migraine headaches is important for reducing the patient burden. This Phase 2b double‐blind, randomized, placebo‐controlled study aimed to assess 12‐week changes in two disease‐specific patient‐reported outcomes (PRO) measures among migraineurs treated with placebo or Galcanezumab.
7min read
Key Take-Away:
In the present study, a case of a 28-year-old sub-Saharan female is presented with insidious onset of painful burning sensations on the upper trunk, symmetrical numbness and tingling sensation on the hands and feet, progressing over a 5 year period. These symptoms began as intermittent burning sensations on the scapulae and pectoral regions of the upper trunk, which progressed to numbness and paraesthesia of the upper and lower limbs respectively. These were associated with mild weakness of the hands and feet, insomnia, irritability and constipation. There were no urinary symptoms, paralysis, gait disturbances, tremors, jaundice, limb swelling, changes in skin colour, or delusion.
20min read
Key Take-Away:
A chronic migraine is linked with a significant number of comorbidities. The study results affirm that the effect and rate of this multimorbidity can be a risk factor for migraine chronification and medication overuse headache also hampers its management.
Introduction:
One of the major risk factors for a chronic migraine (CM) management is the multimorbidity as the patients with CM represent a significant number of comorbidities, especially cardiovascular and psychiatric. The study aims to discuss the effect and the frequency of multimorbidity in CM and medication overuse headache (MOH) patients.
6min read
Key Take-Away:
The ankle sprain is considered as the frequently occurred injuries that lead to chronic ankle instability and impairments like altered balance. The management of such types of sprain can be effectively done using foot orthoses, and this study highlights the performance of new custom-molded foot orthoses with textured surfaces in handling chronic ankle instability.
Introduction:
Chronic ankle instability as a common outcome of ankle sprain leads to numerous impairments such as postural and balance control deficits. Foot orthoses are the frequently used approach for chronic ankle instability recovery. The study directed to estimate the impact of custom-molded foot orthoses with textured surfaces on the chronic ankle instability patients' dynamic balance and to compare their outcomes with different types of foot orthoses.
7min read
Key Take-Away:
One of the major risk factors of knee OA is obesity, the following study results we found body composition and sarcopenic obesity to be associated with the risk of knee OA.
Introduction
As defined by anthropometric measures, obesity is a well‐recognised risk factor for knee osteoarthritis (OA) however, the information concerning knee OA risk and body composition (fat and muscle mass) is relatively insufficient. The analysis investigated the longitudinal connection of body composition divisions based on muscle mass and fat with knee OA.
6min read
Education
Presentations
Vitamins are organic compounds essential for normal physiological functions.
15 min read
Education
Presentations
The World Health Organization (WHO) describes the rational use of medicines as, “patients receive medications appropriate to their clinical needs, in doses that meet their own individual requiremen
5 min read
Education
Smart Guidelines
The guidelines for clinical practice are focused on the preferred approaches to medical problems exhibited by scientifically valid research.
15 min read
Education
Smart Guidelines
Sinusitis affects about 1 in 8 adults in the United States, resulting in over 30 million annual diagnoses.
American Academy of Otolaryngology-Head and Neck Surgery Foundation
15 min read
Education
Smart Guidelines
Chronic pain can be a serious consequence of surviving cancer. The prevalence of pain in cancer survivors has been reported to be as high as 40%.
American Society of Clinical Oncology
10 min read
January 16, 2019
Aromatase inhibitors (AI) are often used as hormone therapy drugs to slow down or pause the enlargement of hormone receptor-positive tumours among postmenopausal women. These inhibitors block aromatase enzyme, thus reducing body estrogen levels and inhibiting the cancer growth. Yhe most common side effects associated with their use are bone loss, increased risk of fractures and osteoporosis.
Key Take-Away:
Migraine is a chronic, prevalent, and multifactorial neurovascular disorder that leads to severe functional disability. Galcanezumab is an effective medication that can prevent the development of migraine and the study validate the Galcanezumab impact among episodic migraineurs by diagnosing the changes in two disease-specific patient-reported outcomes after 12-week treatment.
Introduction
Headache‐associated functional impairment management is a primary goal for PROs and migraine preventive treatment. Recognizing which medications can enhance patient functioning along with managing migraine headaches is important for reducing the patient burden. This Phase 2b double‐blind, randomized, placebo‐controlled study aimed to assess 12‐week changes in two disease‐specific patient‐reported outcomes (PRO) measures among migraineurs treated with placebo or Galcanezumab.
7min read
Education
Presentations
Vitamins are organic compounds essential for normal physiological functions. However, some of them are not synthesized endogenously by the body and therefore have to be sequestered in small quantities from the diet.
15 min read