Oral nimesulide + intra-articular sodium hyaluronate for traumatic knee osteoarthritis

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Created On: 06/01/2026

This study explored the therapeutic benefits of combining oral nimesulide with intra-articular sodium hyaluronate in patients with traumatic knee osteoarthritis.

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Key take away

The combination of oral nimesulide and intra-articular sodium hyaluronate significantly reduces inflammation and pain and improves long-term clinical outcomes in traumatic knee osteoarthritis.

Background

This study explored the therapeutic benefits of combining oral nimesulide with intra-articular sodium hyaluronate in patients with traumatic knee osteoarthritis. The evaluation focused on their impact on inflammatory biomarkers along with changes in pain severity.

Method

A total of 100 traumatic knee osteoarthritis patients were randomly assigned to:

Experimental group (n = 50): Treated with sustained-release oral nimesulide capsules plus sodium hyaluronate injections into the knee joint.
Control group (n = 50): Treated with oral nimesulide alone.

Clinical outcomes were compared using the visual analog scale (VAS), WOMAC scores, inflammatory factor levels, quality-of-life indicators, and treatment effectiveness.

Result

Post-treatment analysis showed that patients in the experimental group experienced markedly lower VAS and WOMAC scores when compared with the control group, indicating greater pain relief and improved joint function. Synovial fluid measures revealed a pronounced decrease in inflammatory biomarkers like matrix metalloproteinase-3 (MMP-3), matrix metalloproteinase-9 (MMP-9), interleukin-1 (IL-1), and tumor necrosis factor-alpha (TNF-α) in the experimental group versus the control group.

The experimental group also illustrated notably higher overall treatment effectiveness. Follow-up at 1, 2, and 3 years showed sustained improvements in physical functioning, social engagement, and psychological well-being in the experimental group, while bodily pain scores remained lower compared to the control group.

Conclusion

Oral nimesulide + sodium hyaluronate injection offers superior therapeutic benefits for traumatic knee osteoarthritis. This approach effectively lowers inflammation, alleviates pain intensity, delays disease progression, and boosts long-term clinical outcomes and quality of life.