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Submucosal injectable platelet-rich fibrin infiltration results in faster recovery, with measurable reductions in swelling, pain scores, and improved healing quality following impacted mandibular third molar surgery.
A randomized controlled trial conducted by a team of investigators aimed to determine whether submucosal injectable platelet-rich fibrin (i-PRF) infiltration could successfully reduce swelling, improve pain control, and enhance wound healing following impacted lower third-molar extraction.
A total of 56 volunteers were randomly allocated to:
Swelling measurements were obtained through a validated flexible-ruler method using Tragus–Pogonion and Gonion–Labial Cleft diagonals at baseline and on postoperative days 3 and 7. Pain scores were documented across 7 postoperative days using a visual analog scale (VAS). Healing progression was evaluated through the Landry Index on days 3, 7, 14, and 21. An additional analysis explored any association between surgical duration and cumulative swelling. The i-PRF group showed a prominent decrease in facial swelling on day 3 compared with controls, a pattern that persisted on day 7 (Table 1).
Pain reduction was also statistically significant. Those treated with i-PRF reported much lower VAS pain scores during the first 3 postoperative days (p < 0.001), suggesting faster relief and reduced reliance on analgesics. Healing outcomes further illustrated the superiority of i-PRF. The test group showed consistently higher Landry healing scores across all evaluated time points—days 3, 7, 14, and 21 (p < 0.05).
Importantly, the duration of surgery did not influence swelling outcomes, meaning benefits were attributed to the biological effect of i-PRF rather than surgical variability. The study confirms that i-PRF provides measurable benefits after impacted third-molar extraction by reducing inflammation, controlling pain, and supporting rapid wound healing. With excellent safety and minimal invasiveness, i-PRF emerges as a promising adjunct that improves patient comfort and may lower postoperative nonsteroidal anti-inflammatory drug (NSAID) use.
Clinical Oral Investigations
Using injectable Platelet-Rich fibrin to improve recovery after impacted lower third molar extraction: a randomized controlled clinical trial
Angelo Aliberti et al.
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