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Renal colic, mainly from ureteral stones, leads to many hospital visits.
Ibuprofen (NSAID) IV 800 mg provides better pain relief for renal colic without increasing side effects, making it the go-to choice for faster, safer, and more effective treatment.
Renal colic, mainly from ureteral stones, leads to many hospital visits. Ibuprofen is preferred over opioids for pain relief, but the optimal intravenous (IV) dose is unclear. This study compared the analgesic effects of ibuprofen IV dosed as 400 mg versus 800 mg in moderate-to-severe renal colic.
The patients with moderate-to-severe renal colic were randomly assigned to receive 400 mg or 800 mg ibuprofen IV 400 mg or 800 mg in this multicenter, randomized, double-blind clinical trial. Using numeric rating scale (NRS), the pain scores were examined at the starting, 15 minutes, 30 minutes, 1 hour and 2 hours. The requirement for additional pain relief and any side effects were also observed.
Altogether, 126 patients completed the study out of 150 patients initially registered. Patients in the 800 mg group had significant pain relief compared to those in the 400 mg group, specifically at 120 minutes (p<0.05). No marked disparity in the need for rescue painkillers or side effects was observed between the study groups.
A dose of 800 mg of IV ibuprofen is more effective for renal colic than 400 mg. Future research is needed to govern optimal dosing and long-term consequences.
Bezmialem Science
Efficacy Comparison of Ibuprofen 400 Mg and 800 mg in the Treatment of Renal Colic: Prospective Randomized Double-blind Clinical Study
Safa Donmez et al.
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