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This study aimed to assess the impact of vitamin C supplementation, with or without flavonoids, on gum health, microbial profiles, and systemic markers prior to and after non-surgical periodontal treatment (NSPT).
Elevated plasma vitamin C levels correlate with reduced gingival inflammation. However, supplementation, with or without flavonoids, does not influence periodontal health.
This study aimed to assess the impact of vitamin C supplementation, with or without flavonoids, on gum health, microbial profiles, and systemic markers prior to and after non-surgical periodontal treatment (NSPT).
A case series stemming from a randomized controlled trial was carried out, enrolling periodontitis patients. The study spanned a 2-month observation phase of untreated periodontitis. This was followed by a 3-month post-NSPT period. Various statistical techniques, including descriptive analysis, correlation studies, clustering, and dimensionality reduction, were applied to determine the interventions' effects.
Due to COVID-19 disruptions, the study was prematurely halted, limiting the analysis to 13 participants. Findings revealed a link between augmented levels of vitamin C in plasma and reduced gum swelling, pointing to potential advantages for untreated periodontal conditions. However, clustering analysis depicted no discernible differences based on supplementation type, indicating it had no vital impact on outcomes. Microbiological data played a minimal role, while principal component analysis visualized clusters without clear distinctions tied to supplementation. Violin plots highlighted individual variability, with one cluster representing patients suffering from more severe periodontal ailments.
While higher plasma vitamin C levels correlated with reduced gingival inflammation, daily supplementation—whether with or without flavonoids—offered no additional advantages for periodontal health before or after NSPT. Findings suggest that disease severity, rather than supplementation, shaped patient outcomes.
Journal of Clinical Medicine
Effect of Daily Vitamin C Supplementation with or Without Flavonoids on Periodontal, Microbial, and Systemic Conditions Before and After Periodontal Therapy: A Case Series from an RCT
Thijs M H de Jong et al.
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