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Adolescence is a crucial stage for establishing long-term health, especially as conditions like polycystic ovarian syndrome (PCOS) can predispose individuals to chronic diseases like diabetes in later life.
Nigella sativa supplementation substantially reduces fasting and two-hour post-prandial glucose levels in adolescents with PCOS.
Adolescence is a crucial stage for establishing long-term health, especially as conditions like polycystic ovarian syndrome (PCOS) can predispose individuals to chronic diseases like diabetes in later life. This secondary analysis of a randomized controlled trial sought to explore the impact of Nigella sativa L. extract on blood glucose regulation in adolescents diagnosed with PCOS.
A total of 116 adolescent girls aged 12 to 18 years with PCOS were randomly allocated to two groups. The intervention group was given 1000 mg of Nigella sativa extract daily for 16 weeks. In contrast, the control group was administered 10 mg of medroxyprogesterone for 10 days during each menstrual cycle throughout the same period. Fasting plasma glucose (FPG), as well as 1-hour and 2-hour post-prandial levels of glucose, were recorded at baseline and post-intervention.
Of the volunteers, 103 finished the study—50 in the Nigella sativa arm and 53 in the control arm. At the start, no vital difference was found in FPG (p = 0.294), although the control group exhibited markedly higher 1-hour (p = 0.002) and 2-hour (p = 0.006) post-prandial glucose levels. Following the intervention, substantial interaction effects were noted for FPG (p = 0.004) and 2-hour post-prandial glucose (p = 0.023), suggesting greater improvements in the Nigella sativa group as opposed to controls.
Nigella sativa supplementation may help improve glycemic control, particularly fasting and two-hour post-prandial glucose levels, in PCOS-affected adolescents. Nonetheless, more research is required to validate these findings and monitor the long-term outcomes.
Journal of Ovarian Research
Effect of Nigella sativa-L supplementation on glycemia in adolescent polycystic ovarian syndrome: secondary analysis of a randomized controlled trial study
Azamsadat Mahmoudian et al.
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