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This study sought to compare the effects of a synbiotic formulation containing herbal extracts with those of a myoinositol-based herbal supplement (MBHS) on acne severity, gut microbiome composition, short-chain fatty acid (SCFA) production, and hormone levels.
Both the synbiotic and myoinositol-based herbal supplement significantly reduce acne lesions and improve gut microbiota and SCFA levels, with the herbal supplement also lowering androgen-related hormones.
This study sought to compare the effects of a synbiotic formulation containing herbal extracts with those of a myoinositol-based herbal supplement (MBHS) on acne severity, gut microbiome composition, short-chain fatty acid (SCFA) production, and hormone levels.
In this 8-week randomized trial, 36 volunteers (both male and female, aged 12–45 years) with non-cystic acne were allocated to get either the synbiotic or the MBHS. Acne lesion counts were assessed, and stool samples were analyzed for microbiome composition and SCFA levels. Hormonal evaluations were executed at baseline and at weeks 4 and 8.
In the synbiotic group, notable increases (≥3-fold) were witnessed in several gut bacteria at both week 4 and 8, including Erysipelatoclostridium merdavium, Blautia argi, Faecalibacterium prausnitzii, Prevotella copri, and others. The MBHS group showed increases in distinct species such as Megamonas funiformis, Ligilactobacillus ruminis, and Prevotella ssp015074785.
Both groups illustrated a statistically significant decrease in acne lesions at week 4 and week 8. Stool and plasma SCFA levels rose markedly or showed upward trends in both groups over time. In the MBHS group, hormone levels of 17-hydroxyprogesterone (17-OHP) and androstenedione substantially declined after 8 weeks (from 27.3 to 11.3 pg/ml and from 94.9 to 68.0 pg/ml respectively).
Both interventions—synbiotic and MBHS—led to improvements in gut microbial diversity, increases in SCFA levels, and reductions in acne lesions. The MBHS may exert additional benefits through the modulation of hormone levels, particularly by lowering 17-OHP and androstenedione.
Dermatology and Therapy
Prospective Comparative Study of an Oral Synbiotic and a Myoinositol-Based Herbal Supplement in Modifying Hormone Levels and the Gut Microbiome in Non-cystic Acne
Mildred Min et al.
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