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This single-center, randomized controlled trial explored the impact of delivering probiotics via colonoscopy on individuals suffering from irritable bowel syndrome with predominant diarrhea (IBS-D).
Probiotics administered via colonoscopy improve IBS-D symptoms, enhancing defecation frequency, stool consistency, and symptom scores without markedly altering gut microbiota diversity.
This single-center, randomized controlled trial explored the impact of delivering probiotics via colonoscopy on individuals suffering from irritable bowel syndrome with predominant diarrhea (IBS-D).
From Jan 2017 to Jan 2018, consecutive outpatients diagnosed with IBS-D based on Rome IV criteria (n = 22) and healthy controls (n = 10) were recruited. IBS-D sufferers were randomized to either the probiotics group or the placebo group. During colonoscopy, a suspension containing live Bifidobacterium and Lactobacillus tablets in saline was sprayed into the right colon for the probiotics group, while the placebo group was given saline alone. At baseline, 2 weeks, and 4 weeks, collection of post-treatment clinical data and stool samples was done.
A total of 29 volunteers completed the study. At 2 weeks, defecation frequency markedly improved in the probiotics group. By 4 weeks, reductions were witnessed in abdominal pain (Visual Analog Score [VAS]) and stool consistency (Bristol Stool Scale).
At 2 weeks post-probiotic administration, the IBS intensity score and gastrointestinal symptom rating scale illustrated remarkable reductions, while the IBS Quality of Life score improved. The overall treatment response was higher in the probiotics group when compared to the placebo group, as shown in Table 1:
Although gut microbiota diversity remained unchanged, the Firmicutes-to-Bacteroidetes ratio dropped in the probiotics group.
Colonoscopic administration of probiotics proved beneficial in alleviating IBS-D symptoms.
Surgical Endoscopy
Colonoscopic administration of probiotics to treat irritable bowel syndrome with predominant diarrhea: a randomized placebo-controlled clinical trial
Jing-Jing Wei et al.
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