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This systematic review and meta-analysis set out to uncover how physical activity influences foot tissue perfusion in individuals living with diabetes mellitus (DM)—a crucial yet often overlooked aspect of diabetic care.
Regular physical activity may boost blood flow in the lower limbs of people with diabetes mellitus.
This systematic review and meta-analysis set out to uncover how physical activity influences foot tissue perfusion in individuals living with diabetes mellitus (DM)—a crucial yet often overlooked aspect of diabetic care.
To ensure methodological rigor, each selected study was appraised utilizing the Cochrane Risk of Bias tool tailored for randomized controlled trials (RCTs). A detailed search strategy was employed across PubMed and Web of Science in April 2024 to capture relevant RCTs and comparative studies. Data were synthesized via RevMan v5.4, with the Mantel-Haenszel approach applied to analyze dichotomous outcomes.
Among the 9 studies reviewed, 7 provided quantifiable data on microcirculatory changes post-exercise in DM sufferers. These yielded a pooled mean difference of 4.87 (95% confidence interval I: 2.37–7.38), favoring exercise-stimulated improvement in microvascular function. Heterogeneity was modest (χ² = 10.54, I² = 43%), and the difference reached strong statistical significance. However, a separate synthesis of 4 studies that included both diabetic and non-diabetic cohorts revealed substantial heterogeneity (χ² = 661.32, I² = 100%) and failed to demonstrate a meaningful difference.
Engagement in physical activity facilitated improved microvascular perfusion in the lower limbs among individuals suffering from diabetes mellitus.
Journal of Tissue Viability
Effect of physical activity on tissue perfusion in patients with diabetes mellitus: Systematic review and meta-analysis
Laura Palacios-Abril et al.
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