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Antimüllerian hormone (AMH) levels and body mass index (BMI) are both known to influence pregnancy outcomes in polycystic ovary syndrome (PCOS) women undergoing in vitro fertilization (IVF).
Overweight or obese women with PCOS and high AMH levels face a significantly increased risk of miscarriage and ovarian hyperstimulation during IVF.
Antimüllerian hormone (AMH) levels and body mass index (BMI) are both known to influence pregnancy outcomes in polycystic ovary syndrome (PCOS) women undergoing in vitro fertilization (IVF). This study monitored how different combinations of AMH levels and BMI affect pregnancy outcomes in women with PCOS undergoing IVF.
This post hoc secondary analysis was based on data from a multicenter randomized trial. Overall, 625 participants from a single center, all of whom had AMH levels assessed before starting IVF, were divided into 6 groups:
Multivariate logistic regression revealed that those in Group F (overweight/obese with high AMH) had a markedly higher risk of clinical pregnancy loss whem compared to Group B, with an adjusted odds ratio (aOR) of 3.30. Additionally, the risk of ovarian hyperstimulation syndrome was increased in both Group C (aOR 3.74) and Group F (aOR 3.61) relative to Group B.
Among women with PCOS undergoing IVF, elevated AMH levels were linked to a higher risk of clinical miscarriage in those who were overweight or obese, but not in those with a normal BMI.
AJOG Global Reports
Effect of different combinations of serum antimüllerian hormone levels and body mass index on pregnancy outcomes in women with polycystic ovary syndrome
Yue Niu et al.
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