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VARIPULSE™ enables effective pulmonary vein isolation and extensive non-pulmonary vein ablation, achieving atrial flutter termination in 96% of cases without major complications.
A new clinical experience highlights the expanding role of pulsed field ablation (PFA) using the VARIPULSE™ variable-loop circular catheter, demonstrating not only effective pulmonary vein isolation (PVI) but also successful mapping and ablation of complex non-pulmonary vein (non-PV) targets in atrial fibrillation (AF).
In this retrospective analysis, 60 patients with paroxysmal or persistent AF underwent catheter ablation using the fully integrated VARIPULSE™ system within a three-dimensional mapping platform.
PVI using PFA was performed in all patients, following protocol-driven strategy. A substantial proportion of patients required additional substrate modification beyond PVI:
Notably, 27 patients developed atrial flutters during the index procedure, which were mapped and ablated using the VARIPULSE catheter. Termination of atrial flutter was achieved in all but one patient, underscoring the platform’s mapping precision and ablation effectiveness in complex atrial arrhythmias. Importantly, no major complications were detected, supporting the safety profile of PFA technology even when extended to non-PV targets and atypical atrial flutter circuits.
While PFA is increasingly adopted for PVI, evidence regarding its application to non-PV substrates has remained limited. This study demonstrates that the VARIPULSE™ PFA catheter enables:
Journal of Clinical Medicine
Single-Center Real World Experience with the VARIPULSE Platform for Pulsed Field Ablation of Atrial Fibrillation, Atrial Flutter, and Redo Procedures
Nizar Andria et al.
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