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Combination therapy with ciclopirox 8%, photodynamic sessions, and debridement achieves 100% mycological and 90% clinical cure in diabetic foot onychomycosis without side effects.
As per the outcomes of a prospective case series published in "Journal of Clinical Medicine", combining ciclopirox 8% topical treatment with photodynamic therapy and monthly debridement results in a 100% mycological cure rate and 90% clinical cure rate in patients with diabetic foot onychomycosis—without any reported side effects.
The study included 10 patients, regardless of comorbidities or infection severity. All participants received daily applications of ciclopirox 8%, a lacquer containing ethyl acetate, 96% ethanol, hydroxypropyl chitosan, ketostearyl alcohol, and purified water, for six months. This was combined with 3 sessions of photodynamic therapy (within the first two months) via toluidine blue gel and a 635 nm diode laser, along with monthly nail debridement. Upon study completion:
In addition, the Onychomycosis Severity Index (OSI) showed remarkable improvement, dropping from 18.50 ± 8.95 at baseline to 10.30 ± 6.13 at 3 months, and further down to 4.10 ± 4.08 after 6 months. The findings suggest that the integrated use of ciclopirox 8%, photodynamic therapy, and mechanical debridement can boost outcomes in diabetic patients with onychomycosis, offering a safe and effective alternative to systemic therapy.
Journal of Clinical Medicine
Red-Laser Photodynamic Therapy with Toluidine Blue Gel as an Adjuvant to Topical Antifungal Treatments for Onychomycosis in Patients with Diabetes: A Prospective Case Series
David Navarro-Pérez et al.
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