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Hepatitis A vaccine is safe and highly effective in adults, with a single dose triggering strong immunity and a second dose boosting protection to 100% across all age groups.
A new clinical investigation has offered encouraging news for adult vaccination: the hepatitis A vaccine is not only safe but highly effective, whether given as a single shot or as part of a two-dose schedule.
More than 1,000 adults, aged 18 and older, took part in the trial. Before vaccination, blood tests revealed that just over half of the participants (52.56%) already had antibodies against the hepatitis A virus. Surprisingly, the lowest natural immunity was seen in people aged 36 to 40 years, suggesting this age group may be particularly vulnerable. All participants received one dose of the hepatitis A vaccine. Those who tested negative for antibodies were then divided into groups, with some given a second dose at different intervals. Researchers tracked antibody levels after each vaccination and monitored side effects for nearly a month.
The results were striking!
The study’s interim findings reinforce that the hepatitis A vaccine yields robust protection with just one dose, while a second dose ensures complete and long-lasting immunity.
Human Vaccines & Immunotherapeutics
Immunogenicity and safety of hepatitis A vaccine at different vaccination intervals among adults aged 18 years and above: Interim results
Lin Chang et al.
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