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Ultrasound is at least as useful as conventional X-ray images in the diagnosis of ankle sprain-related fractures, notwithstanding age or sex and could, in fact, be better, as mentioned in the 'European Journal of Trauma and Emergency Surgery'. In traumatology, Ankle torque is the most commonly encountered injury mechanism. It mostly develops as an ankle sprain and often leads to an ankle fracture.

8min read    

The arthroscopic primary repair results in a good objective and subjective outcomes at a follow-up of 3.2-year in a carefully selected population, as explained in a study published in 'Knee Surgery, Sports Traumatology, Arthroscopy'. In the small cohorts, the recent outcomes of arthroscopic primary repair of proximal anterior cruciate ligament (ACL) tears have been found to be positive.

8min read    

In some individuals, chronic pain management remains ineffective and due to which intake of opioids is increased, which lead to severe consequences. As per a Protocol of a systematic review published in the journal JMIR, administration of magnesium either orally or parenterally may emerge as an efficient and safe approach to treat such type of chronic pain in the future.

7min read    

A 20 mg Piroxicam or 75 mg Diclofenac sodium intramuscularly show similar results in treating primary dysmenorrhea in the emergency unit, as per a research published in the Medical Science Monitor. NSAIDs are considered as the frequently used agents in treating dysmenorrhea as they help to alleviate menstrual pain by decreasing PGF2alpha levels and uterine pressure in the menstrual fluid.

6min read    

Autologous transplantation of bone marrow mononuclear cells (BMMNCs) emerges as a promising and practical approach to treat refractory diabetic peripheral neuropathy (DPN) as per the research led by investigators of Nanyang Technological University and Huazhong University of Science and Technology. Due to the multifactorial characteristics of the DPN pathogenesis, traditional drug treatments have not been efficient.

6min read    
Key Take-Away:

This study confirmed the evidence that dydrogesterone effectively reduced dysmenorrhea pain symptoms and did not repress ovulation during oral administration. This is the 1st study to establish that dydrogesterone is the only hormonal drug which can be permitted to get pregnant during its administration. It also renders efficacy and safety for the treatment of endometriosis with dysmenorrhea. 

Introduction:

The efficacy and safety of dydrogesterone in Japanese women suffering from dysmenorrhea has been evaluated in this study.

8min read    
Key Take-Away:

This retrospective review by Ryan J Diel et al. depicted that photophobia and dry eye symptom improvement after administration of BoNT-A injections in patients treated for migraine pain occurred independent of baseline tear volume at the baseline. The modulation of shared trigeminal neural pathways may play a crucial role in the same.

Introduction:

To examine the efficacy of botulinum toxin A (BoNT-A) in decreasing photophobia and dry eye symptoms in patients with chronic migraine. Also, the investigators focused on evaluating tear film volume as a promising contributor to the symptoms in these migraine patients.

8min read    
Key Take-Away:

Pregabalin belongs to the class of anticonvulsants, which works by reducing the number of pain signals sent out by impaired nerves in the body. All the analyses of pain and sleep scores (MMRM and LOCF) in this study were significant at all time points for subjects with type 2 diabetes mellitus. 

Introduction:

This study aimed to compare the efficacy and safety of pregabalin for painful diabetic peripheral neuropathy (pDPN) in type 1 (T1DM) or 2 diabetes mellitus (T2DM) subjects.

8min read    
Key Take-Away:

Albilia JB DMD et al. found out that intra-articular injections of liquid PRF appear to have significant analgesic effects lasting for 12 months in patients with localized painful internal derangement of the temporomandibular joint (TMJ), which is only one of many synovial joint diseases. In this preliminary investigation, patients suffering from Wilkes' stage IV (intermediate-late) and stage V (late) respond the best to this particular second-generation blood concentrate.

Introduction:

To examine the clinical advantages of liquid platelet-rich fibrin (PRF) in patients with temporomandibular joint (TMJ) pain and dysfunction.

6min read    
Key Take-Away:

This is the first study which compared baricitinib 2 mg versus 4 mg in patients with rheumatic arthritis (RA). The total adverse events, discontinuation of the drug due to adverse events, malignancies, major adverse cardiac events, infections like herpes zoster, and serious infections were significantly higher between the two doses of Baricitinib at 24 weeks follow-up.

Introduction:

On 23 April 2018, the FDA-based Advisory Committee approved the use of baricitinib 2 mg for RA treatment and suggested the possibility of serious adverse events associated with baricitinib 4 mg. Therefore, the authors aimed to systematically distinguish between the risk of adverse drug events observed with baricitinib 2 mg against 4 mg for the treatment of RA patients.

9min read    
Education
Smart Guidelines

Hand osteoarthritis (OA) is a common musculoskeletal disease, associated with hand pain, stiffness, functional limitation, decreased grip strength and reduced quality of life.

2min read    
Education
Smart Guidelines

Pain is the leading cause of suffering, disability and medical care worldwide.

10 min read    
Education
Presentations

Arthritis encompasses more than 100 different arthritic conditions which are a chronic, painful, and debilitating group of diseases.

15 min read    
Education
Presentations

Rheumatoid arthritis (RA) is a chronic inflammatory disorder with an estimated prevalence of 0.5-1% of the population worldwide; it is also reported that women are more affected than men are. [1].

15 min read    
Education
Presentations

Vitamins are organic compounds essential for normal physiological functions.

15 min read    
July 30, 2019

Ultrasound is at least as useful as conventional X-ray images in the diagnosis of ankle sprain-related fractures, notwithstanding age or sex and could, in fact, be better, as mentioned in the 'European Journal of Trauma and Emergency Surgery'. In traumatology, Ankle torque is the most commonly encountered injury mechanism. It mostly develops as an ankle sprain and often leads to an ankle fracture.

Key Take-Away:

This study confirmed the evidence that dydrogesterone effectively reduced dysmenorrhea pain symptoms and did not repress ovulation during oral administration. This is the 1st study to establish that dydrogesterone is the only hormonal drug which can be permitted to get pregnant during its administration. It also renders efficacy and safety for the treatment of endometriosis with dysmenorrhea. 

Introduction:

The efficacy and safety of dydrogesterone in Japanese women suffering from dysmenorrhea has been evaluated in this study.

8min read    
Education
Smart Guidelines

Hand osteoarthritis (OA) is a common musculoskeletal disease, associated with hand pain, stiffness, functional limitation, decreased grip strength and reduced quality of life. Its incidence increases with increasing age.

2min read