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The recent strategy for rheumatoid arthritis (RA) management mainly focuses on achieving clinical remission. After the remission is attained and sustained over time, the better efficient strategy is dose optimization. The recent study published in Rheumatology International explained the results of dose optimization after 2 years of follow-up in patients with RA treated with biological therapy and identifies predictive variables of response.

7min read    

A recent study by Kumar et al, published in Current Orthopaedic Practice found methotrexate (MTX) as a safe and effective choice of treatment among rheumatoid arthritis (RA) patients.  

8min read    

A recent study published in Nutritional Neuroscience has revealed that intake of omega-3 fatty acid leads to a significant reduction in the duration of a migraine attacks.

8min read    

Osteoarthritis (OA) is one of the most chronic conditions of joints leading to pain and disability. This disease affects more than 3 million Americans.  It causes severe inflammation, pain and restricted movement and severe osteoarthritis may require a knee replacement surgery. According to a research by Dr Monte Hunter and colleagues published in the journal Scientific Reports, males and females respond differently to OA. This may be attributed to the findings involving the synovial fluid in the joints. Researchers found the difference between the messages sent and received via mRNA. Therefore, scientists looked for what messenger cells in the affected region were sending and receiving the signals. The probe was done by studying the inner travelling compartments in the fluid, known as exosomes. They found an altered number of mRNA in both the patient groups. However, no difference was seen in the number of exosomes.

10min read    

The recent strategy for rheumatoid arthritis (RA) management mainly focuses on achieving clinical remission. After the remission is attained and sustained over time, the better efficient strategy is dose optimization. The recent study published in Rheumatology International explained the results of dose optimization after 2 years of follow-up in patients with RA treated with biological therapy and identifies predictive variables of response.

7min read    
Key Take-Away:

Dexmedetomidine-ketamine combination is a safe alternative for sedation during the cardiac catheterization procedure without the incidence of any hemodynamic or respiratory effects. However, it is associated with some delayed recovery. 

Management of children with congenital heart disease is challenging for anesthesiologists, especially during cardiac catheterization. 

Joshi VS, Kollu SS, Sharma RM. Ann Card Anaesth 2017;20:422-6
18min read    
Key Take-Away:

There is moderate-to high-quality evidence that anticonvulsants are ineffective for the treatment of low back pain or lumbar radicular pain. There is high-quality evidence that gabapentinoids have a higher risk of adverse events.

Globally, millions of people are suffered from low back pain (LBP) and become a major cause of disability than any other health complication. It is predicted that about 5% to 10% of patients with LBP have sciatica and followed by leg pain.

CMAJ. 2018 Jul 3;190(26):E786-93.
18min read    
Key Take-Away:

In patients with gout and major cardiovascular coexisting conditions, febuxostat was non-inferior to allopurinol with respect to rates of adverse cardiovascular events.

Gout is a chronic inflammatory disorder characterised by hyperuricemia, arthropathy, tophus development, and urolithiasis. Gout is reported to be associated with an increased risk of cardiovascular and chronic kidney disease. 

N Engl J Med. 2018 Mar 29;378(13):1200-1210
18min read    
Key Take-Away:

Baricitinib alone or in combination with methotrexate, when used as initial therapyleads to a significant improvement in rheumatoid arthritis as compared to methotrexate alone.

Rheumatoid arthritis (RA) patients often suffer from number of restrictions in daily life due to frequent pain, fatigue, sleep disturbance and functional impairment in work and physical activities. 

Arthritis research & therapy. 2017 Dec;19(1):208.
25min read    
Key Take-Away:

Radiographic findings including joint space narrowing and MRI detected bone marrow lesions, synovitis and effusion are significantly associated with the long term risk of total knee arthroplasty (TKA)  in knee osteoarthritis patients.

Osteoarthritis (OA) is the most chronic joint disorder with an estimated prevalence of 15% worldwide, mainly affecting population aged between 56 to 84. Previous studies reported that aging and obesity were strongly associated with OA.

BMC Musculoskelet Disord. 2017; 18: 510.
16min read    
Education

Sinusitis affects about 1 in 8 adults in the United States, resulting in over 30 million annual diagnoses.

American Academy of Otolaryngology-Head and Neck Surgery Foundation
15 min read    
Education

Chronic pain can be a serious consequence of surviving cancer. The prevalence of pain in cancer survivors has been reported to be as high as 40%.

American Society of Clinical Oncology
10 min read    
Education

Neuropathic pain is defined as the pain initiated or caused by a primary lesion, dysfunction, or transitory perturbation of peripheral or central nervous system.

Western Australian Therapeutic Advisory Group
2min read    
Education

Transitional care, as defined by the Society for Adolescent Medicine refers to the purposeful, planned movement of adolescents and young adults with chronic physical and medical conditions from chi

Ann Rheum Dis 2016;0:1–8
4min read    
Education

As per the World Health Organization (WHO), osteoporosis refers to a progressive systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of the bone tissues, w

Arch Osteoporos. 2017; 12(1): 43.
2min read    
July 13, 2018

The recent strategy for rheumatoid arthritis (RA) management mainly focuses on achieving clinical remission. After the remission is attained and sustained over time, the better efficient strategy is dose optimization. The recent study published in Rheumatology International explained the results of dose optimization after 2 years of follow-up in patients with RA treated with biological therapy and identifies predictive variables of response.

Key Take-Away:

Dexmedetomidine-ketamine combination is a safe alternative for sedation during the cardiac catheterization procedure without the incidence of any hemodynamic or respiratory effects. However, it is associated with some delayed recovery. 

Management of children with congenital heart disease is challenging for anesthesiologists, especially during cardiac catheterization. 

Joshi VS, Kollu SS, Sharma RM. Ann Card Anaesth 2017;20:422-6
18min read    
Education

Sinusitis affects about 1 in 8 adults in the United States, resulting in over 30 million annual diagnoses. Sinusitis is the fifth most common diagnosis in the world; more than 1 in 5 antibiotics prescribed in adults are for sinusitis. Irrespective of the high incidence and economic burden of sinusitis, significant practice dissimilarities exist through and within the numerous disciplines involved in managing the condition. The guideline is applicable for patients aged 18 years and above with a clinical diagnosis of uncomplicated rhinosinusitis.

American Academy of Otolaryngology-Head and Neck Surgery Foundation
15 min read