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Efficacy and safety of single injection of cross-linked Sodium hyaluronate versus three injections of high molecular weight Sodium hyaluronate for knee osteoarthritis

Knee osteoarthritis (OA) is one of the major causes of disability throughout the world. OA was designated as the fourth leading cause of years lived with disability at global level reporting for 3.0% of total global years lived with disability (YLDs) in 2000 according to the World Health Report. The loss of hyaluronan in the synovial fluid and cartilage of the knee cause joint pain and stiffness in knee OA patients.

HA CW et al. executed a randomized, multi-center, double-blind, non-inferiority study to investigate the efficacy and safety of a cross-linked hyaluronate (XLHA, single injection form) distinguished with a linear high molecular hyaluronate (HMWHA, thrice injection form) in symptomatic knee osteoarthritis patients.

9min read
News
Pain Management
Comparison of long-term outcomes between navigated and conventional total knee arthroplasty

Total knee arthroplasty (TKA) is major surgery and liable to post-operative complications and infection is one of the worst and most feared issues. It represents an actual challenge to the orthopaedic surgeon since it is complicated and lengthy to treat. In navigation-assisted TKA, the bone cuts were extramedullary-guided and mapped via navigation and infrared-based systems as per the manufacturer’s instructions. In case of conventional TKA, the femoral bone cuts (distal and chamber cuts) were directed by an intramedullary system and guiding instruments.

8min read
News
Pain Management
Effect of Ketoprofen and Dexketoprofen in the management of acute postoperative pain

Patients undergoing surgical procedures experience acute or sometimes chronic postoperative pain.  This pain can be managed through certain pain relief medicines such as Ketoprofen and Dexketoprofen. Both these drugs are analgesic non-selective nonsteroidal anti-inflammatory drugs (NSAIDs). Theoretically, Dexketoprofen at half the dose as compared to Ketoprofen imparts equivalent analgesic effect with lower gastrointestinal adverse events. This review was executed to evaluate individual reviews brought together in two overviews to provide information about the relative efficacy and harm of various interventions.

14min read
News
Pain Management
Chronic back pain patients can learn control over spinal nociception

Recently, a study published in "European Journal of Pain" demonstrated a significant reduction in spinal nociception of chronic back pain patients and also improved their descending pain inhibition under nociceptive flexor reflex (RIII reflex) feedback training.

7min read
News
Pain Management
The link between Self-Reported Low Back Pain and Radiographic Lumbar Disc Degeneration

Lately, a study conducted by Van den Berg R and colleagues demonstrated the association between disc space narrowing and neuropathic pain for the very first time. However, no significant relationship was found between osteophytes and LBP.

8min read
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Science
Clinical Research
Efficacy, safety, and pharmacokinetics of intravenous ibuprofen for fever in hospitalized pediatric patients
Key Take-Away:

Fever is one of the common symptom in medical evaluation in infants and children accounting for about 65% ambulatory pediatric visits. At a temperature higher than 38.3 °C [101Fahrenheit (F), antipyretic medication is indicated.

Samia N. Khalil et al. BMC Pediatrics. 2017; 17:42
15min read
Science
Clinical Research
Tocilizumab offers low immunogenicity in rheumatoid arthritis patients
Key Take-Away:

Biologic DMARDs (bDMARDs) are first-line treatment agents for RA patients not responding to or intolerant to csDMARDs. The currently approved bDMARDs include anti-tumor necrosis factor-α agents (aTNFs), Anti-interleukin 6 receptor (IL-6R) therapy, Anti-CD20 B cell targeted therapy and T cell co-stimulation inhibition. 

Annals of the Rheumatic Diseases. 22 December 2016
15min read
Science
Clinical Research
Long-term safety of Adalimumab: infections, vaccination response and pregnancy outcomes in rheumatoid arthritis patients
Key Take-Away:

Tumor necrosis factor inhibitors (TNFi or anti-TNFs) have significantly contributed in improving the clinical outcomes of rheumatoid arthritis (RA), however, safety has always been a concern. Various severe infectious event (SIE) have been reported in patients using biologics. 

Burmester GR et al. Annals of the Rheumatic Diseases 2017; 76:414-417.
17min read
Science
Clinical Research
Effectiveness of transdermal delivery of corticosteroids in improving arthritis pain and functional disability
Key Take-Away:

Transdermal delivery of betamethasone valerate shows a considerable safety and efficacy in arthritis and osteoarthritis patients.

Arthritis is marked by joint pain and inflammation. The most common form of arthritis is osteoarthritis (OA) which can be described as a degenerative mesenchymal disease, affecting approximately 10% of the world’s population over 60 years.

Drug Deliv. and Transl. Res. (2017) 7:156–161
17min read
Science
Clinical Research
Serum Procalcitonin as a Potential Marker for Differential Diagnosis of Acute Gouty Attack and Bacterial Infection
Key Take-Away:

Serum procalcitonin (PCT) levels found to be significantly lower in patients with the acute gouty attack than in patients with bacterial infection.

The acute gouty attack is an inflammatory response in which monosodium urate crystals get deposited in joints. It is characterized by redness, tenderness, swelling, and heat over inflamed joints, and systemic fever.

Yonsei Med J 2016 Sep;57(5):1139-1144
18min read
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Education
Smart Guidelines
An Update on the Clinical Practice Guidelines for Adult Sinusitis

Sinusitis affects about 1 in 8 adults in the United States, resulting in over 30 million annual diagnoses.

American Academy of Otolaryngology-Head and Neck Surgery Foundation
15 min read
Education
Smart Guidelines
Management of Chronic Pain in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline

Chronic pain can be a serious consequence of surviving cancer. The prevalence of pain in cancer survivors has been reported to be as high as 40%.

American Society of Clinical Oncology
10 min read
Education
Smart Guidelines
Guidelines for Pharmacological Treatment of Neuropathic Pain

Neuropathic pain is defined as the pain initiated or caused by a primary lesion, dysfunction, or transitory perturbation of peripheral or central nervous system.

Western Australian Therapeutic Advisory Group
2min read
Education
Smart Guidelines
EULAR/PRES Standards and Recommendations for the Transitional care of young people with Juvenile-onset Rheumatic disease

Transitional care, as defined by the Society for Adolescent Medicine refers to the purposeful, planned movement of adolescents and young adults with chronic physical and medical conditions from chi

Ann Rheum Dis 2016;0:1–8
4min read
Education
Smart Guidelines
The NOGG 2017 Clinical Guideline for the Prevention and Treatment of Osteoporosis

As per the World Health Organization (WHO), osteoporosis refers to a progressive systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of the bone tissues, w

Arch Osteoporos. 2017; 12(1): 43.
2min read
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News
Pain Management
May 18, 2018
Efficacy and safety of single injection of cross-linked Sodium hyaluronate versus three injections of high molecular weight Sodium hyaluronate for knee osteoarthritis

Knee osteoarthritis (OA) is one of the major causes of disability throughout the world. OA was designated as the fourth leading cause of years lived with disability at global level reporting for 3.0% of total global years lived with disability (YLDs) in 2000 according to the World Health Report. The loss of hyaluronan in the synovial fluid and cartilage of the knee cause joint pain and stiffness in knee OA patients.

HA CW et al. executed a randomized, multi-center, double-blind, non-inferiority study to investigate the efficacy and safety of a cross-linked hyaluronate (XLHA, single injection form) distinguished with a linear high molecular hyaluronate (HMWHA, thrice injection form) in symptomatic knee osteoarthritis patients.

9min read
more articles >
Science
Clinical Research
Efficacy, safety, and pharmacokinetics of intravenous ibuprofen for fever in hospitalized pediatric patients

Fever is one of the common symptom in medical evaluation in infants and children accounting for about 65% ambulatory pediatric visits.

Samia N. Khalil et al. BMC Pediatrics. 2017; 17:42
15min read
more articles >
Education
Smart Guidelines
An Update on the Clinical Practice Guidelines for Adult Sinusitis

Sinusitis affects about 1 in 8 adults in the United States, resulting in over 30 million annual diagnoses. Sinusitis is the fifth most common diagnosis in the world; more than 1 in 5 antibiotics prescribed in adults are for sinusitis. Irrespective of the high incidence and economic burden of sinusitis, significant practice dissimilarities exist through and within the numerous disciplines involved in managing the condition. The guideline is applicable for patients aged 18 years and above with a clinical diagnosis of uncomplicated rhinosinusitis.

American Academy of Otolaryngology-Head and Neck Surgery Foundation
15 min read