Restless legs syndrome (RLS), an urge to move the legs is a sensorimotor and circadian sleep disorder. The recent meta-analysis found that the migraine patients are at higher risk of developing RLS. A number of previously conducted studies also showed this relationship, but the data had considerable variations.
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The Tofacitinib, a JAK inhibitor presents the excellent potential for psoriasis and psoriatic arthritis treatment, as per recent research carried out by the scientists of Chapel Allerton Hospital and Bradford Teaching Hospitals. These are the immune-mediated health issues leading to significant functional disability and reduced quality of life. Further, due to clinical heterogeneity associated with these problems, the management becomes difficult.
6min read
As per a recently published systematic review and meta-analysis in the Journal, Rheumatology International, out of the five major classes of drugs; oral NSAIDs, topical NSAIDs, COX-2 inhibitors, opioids and acetaminophen; topical NSAIDs exhibited higher efficiency in the management of osteoarthritis-associated pain.
7min read
According to a current observational cohort study published in the Journal Headache, 3.16% of patients who underwent catheter‐based cerebral angiography were experiencing the episodes of a migraine headache. Cerebral angiography, an x-ray examination method is the most reliable mode to inspect the blood vessels of the brain by inserting a catheter through a small cut in the skin of leg or arm.
7min read
The diabetic peripheral neuropathy could be managed with non-pharmacological interventions like alpha-lipoic acid and spinal cord stimulation; said the scientists of Hopkin Hospital, Baltimore, USA.
Some diabetic neuropathy patients may not be adequately relieved with conventional therapies or may face adverse effects. Thus, the scientists focused on evaluating the efficacy and safety of some non-pharmacological treatments by conducting a systematic analytical review.
7min read
Key Take-Away:
Biological disease-modifying antirheumatic drugs (bDMARDs) are genetically engineered to act like natural proteins in the immune system which have a significant contribution to the treatment of RA for many years. This prospective study by Killinger Z et al. depicted that treatment with bDMARDS decreased the mean prednisone dose and led to an increase in the trabecular bone score (TBS).
Introduction:
Biologic treatment may influence the RA, as well as areal bone mineral density (aBMD). Decreased aBMD portrays that the fracture risk in RA patients only partially. The trabecular bone score (TBS), a novel texture parameter reflects the degradation of trabecular bone and hence could be used as a further parameter to foretell the risk of fragility fracture. This study aimed to compare the effects of bDMARDs and conventional synthetic (cs) DMARDs (methotrexate) on aBMD and TBS in active RA patients.
8min read
Key Take-Away:
‘Distal tibial fracture' is a heterogeneous group of fractures comprising the distal part of both tibia and fibula. This comparative analysis concluded that the clinical and radiological outcomes such as; the rate of infections, wound complications, malunion and anterior knee pain were found to be almost similar in both intramedullary nailing (IMN) and locked plate (LP) procedures.
Introduction:
This study aimed to compare the clinical and radiological outcome of IMN and LP in patients affected by fracture of distal tibia (DTF). The predictive factors of an unfavourable outcome were also identified.
7min read
Key Take-Away:
The radial head is an important secondary stabiliser of the elbow against valgus loading, and the fractures of radial head are common. This retrospective case series showed that the patients recovered a median flexion arch of 113°; hence most of them are classed as satisfactory outcomes which can be expected midterm when using pyrocarbon prostheses.
Introduction:
This study aimed to elucidate the mid-term radiological findings in patients with a pyrocarbon radial head prosthesis and to correspond them to patient symptoms.
7min read
Intravenous Acetaminophen Improves Outcomes After Transapical Transcatheter Aortic Valve Replacement
Key Take-Away:
The Transapical approach (TA) is an established access substitute for the transfemoral method in patients undergoing transcatheter aortic valve replacement (TAVR) for the symptomatic aortic valve stenosis treatment. This retrospective study pointed out that the patients who received intravenous acetaminophen used significantly fewer morphine equivalents on and had a shorter median length of stay.
Introduction:
Complications with opioid-based postoperative pain management have led to guideline recommendations for a multimodal analgesia strategy incorporating nonopioid agents. The opioid-sparing effect of intravenous acetaminophen in patients undergoing transapical transcatheter aortic valve replacement was evaluated.
7min read
Key Take-Away:
As per the American College of Rheumatology, in patients with OA and meniscal tear, the presence or persistence of effusion-synovitis can be connected with the progression of cartilage damage. This study portrayed that persistently extensive effusion-synovitis had a statistically significant increased risk of cartilage damage depth progression than those with persistently minimal effusion-synovitis.
Introduction:
Synovitis is a characteristic of knee osteoarthritis (OA) and meniscal tear. It has been concerned with articular cartilage damage. This study investigated the associations between baseline and changes in effusion-synovitis and cartilage damage in a cohort with OA and meniscal tear.
7min read
Education
Presentations
Arthritis encompasses more than 100 different arthritic conditions which are a chronic, painful, and debilitating group of diseases.
15 min read
Education
Presentations
Rheumatoid arthritis (RA) is a chronic inflammatory disorder with an estimated prevalence of 0.5-1% of the population worldwide; it is also reported that women are more affected than men are. [1].
15 min read
Education
Presentations
Vitamins are organic compounds essential for normal physiological functions.
15 min read
Education
Presentations
The World Health Organization (WHO) describes the rational use of medicines as, “patients receive medications appropriate to their clinical needs, in doses that meet their own individual requiremen
5 min read
Education
Smart Guidelines
The guidelines for clinical practice are focused on the preferred approaches to medical problems exhibited by scientifically valid research.
15 min read
February 18, 2019
Restless legs syndrome (RLS), an urge to move the legs is a sensorimotor and circadian sleep disorder. The recent meta-analysis found that the migraine patients are at higher risk of developing RLS. A number of previously conducted studies also showed this relationship, but the data had considerable variations.
Key Take-Away:
Biological disease-modifying antirheumatic drugs (bDMARDs) are genetically engineered to act like natural proteins in the immune system which have a significant contribution to the treatment of RA for many years. This prospective study by Killinger Z et al. depicted that treatment with bDMARDS decreased the mean prednisone dose and led to an increase in the trabecular bone score (TBS).
Introduction:
Biologic treatment may influence the RA, as well as areal bone mineral density (aBMD). Decreased aBMD portrays that the fracture risk in RA patients only partially. The trabecular bone score (TBS), a novel texture parameter reflects the degradation of trabecular bone and hence could be used as a further parameter to foretell the risk of fragility fracture. This study aimed to compare the effects of bDMARDs and conventional synthetic (cs) DMARDs (methotrexate) on aBMD and TBS in active RA patients.
8min read
Education
Presentations
Arthritis encompasses more than 100 different arthritic conditions which are a chronic, painful, and debilitating group of diseases.
15 min read