Categories
Change Password!
Reset Password!
Serum diamine oxidase levels are lower in people with allergic asthma and/or allergic rhinitis when compared to healthy controls. It also shows good discriminatory performance, with a 22.2 U/mL cutoff achieving 80% sensitivity and 87% specificity.
Could altered histamine metabolism yield a novel clue to allergic respiratory diseases? A cross-sectional study suggests that serum diamine oxidase (DAO), an enzyme implicated in extracellular histamine degradation, may help distinguish patients suffering from allergic asthma and/or allergic rhinitis (AR) from healthy individuals.
The cross-sectional study included 141 subjects with allergic asthma and/or AR and 78 healthy controls. Serum DAO was estimated via enzyme-linked immunosorbent assay (ELISA), alongside total immunoglobulin E (IgE), eosinophil count, spirometric parameters, and eosinophil cationic protein.
The median serum DAO concentration was 13.8 U/mL in patients with allergic disease versus 28.2 U/mL in healthy controls. Low DAO levels below 10 U/mL were also more common in the allergic group (32.6% vs 2.6%). Although DAO concentrations differed markedly between groups, they were not associated with age, gender, total IgE, eosinophil indices, eosinophil cationic protein, or pulmonary function parameters.
This indicates that the lower circulating DAO concentrations did not correspond directly with the conventional immunological and respiratory measures assessed in the study. Receiver operating characteristic analysis illustrated an area under the curve (AUC) of 0.84. At the 22.2 U/mL cutoff, serum DAO attained 80% sensitivity and 87% specificity for discriminating allergic asthma and/or AR sufferers.
To sum up, lower serum DAO concentrations may help distinguish those with allergic asthma and/or AR from healthy individuals. Although the observed diagnostic performance is promising, external validation and further mechanistic research are prudent before DAO can be considered a clinically useful biomarker.
Medicine (Baltimore)
Serum diamine oxidase levels in allergic asthma and/or allergic rhinitis
Ilkay Keskinel et al.
Comments (0)