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Reflux oesophagitis, a common form of gastroesophageal reflux disease (GERD), is frequently diagnosed in both gastroenterology and primary care settings.
Patients taking calcium channel blockers, theophylline, or NSAIDs face a higher likelihood of reflux oesophagitis.
Reflux oesophagitis, a common form of gastroesophageal reflux disease (GERD), is frequently diagnosed in both gastroenterology and primary care settings. This study investigated the prevalence of reflux oesophagitis and identified key risk factors, with a special focus on medication usage.
Researchers analyzed data from patients who underwent oesophagogastroduodenoscopy (OGD) at a major tertiary care center in Tokyo, Japan. A total of 13,993 patients were included. Structured questionnaires captured detailed information on demographics, lifestyle factors (smoking, alcohol consumption), medical history, and current medication use at the time of endoscopy.
In this retrospective cross-sectional study, the overall prevalence of reflux oesophagitis was 11.8%, highlighting its substantial clinical burden. Multivariate logistic regression identified numerous independent risk factors for reflux oesophagitis, as depicted in Table 1:
Medication-associated risks were as follows:
These findings highlight that commonly prescribed medications for cardiovascular and respiratory conditions, as well as pain management drugs, may escalate reflux oesophagitis risk.
Reflux oesophagitis impacts 11.8% of patients undergoing endoscopy. Both lifestyle factors and medication use play a crucial role. Clinicians must consider modifying high-risk medications, especially in those with GERD symptoms or predisposing ailments.
BMJ Open Gastroenterology
Medication use and risk of reflux oesophagitis
Ren Ueta et al.
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