Researchers examined the FLUID Trial database to evaluate the correlation between fluid infusion rates and outcomes in overweight or obese individuals.

Children and adolescents underwent meticulous categorization based on their weight, including classifications such as overweight, obese, or within the normal weight range. The investigation delved into the connections between outcomes and the quantity of fluid administered within these groups.  Rigorous assessments systematically gauged protocol adherence, monitored mental status changes, quantified the time required for DKA resolution, and identified electrolyte abnormalities.

Children and adolescents with obesity were prone to receiving fluids at rates slower than prescribed by the protocol. However, overweight and obese individuals in the fast fluid groups, who were administered fluids as per the study protocol based on their measured weight, exhibited comparable rates of mental status alterations or clinically evident cerebral injury as those having normal weights.

Hypophosphatemia risk was higher in those getting larger initial bolus volumes but decreased in those getting elevated rehydration rates. There were no other metabolic outcomes linked to the rehydration process.

Clinicians are advised not to restrict fluid resuscitation in obese kids and youth experiencing DKA.