Efficacy of ibuprofen and acetaminophen in closing patent ductus arteriosus :- Medznat
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Two renowned COX inhibitors show no discrepancy in treating patent ductus arteriosus

Patent ductus arteriosus Patent ductus arteriosus
Patent ductus arteriosus Patent ductus arteriosus

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Both ibuprofen and acetaminophen are effective and safe for the closure of patent ductus arteriosus in preterm neonates (a congenital heart condition), posing as flexible treatment options for healthcare providers.

In the ongoing pursuit of effective treatments for patent ductus arteriosus (PDA) in premature newborns, a systematic review by Halecy Davidson Sousa da Silva et al. has highlighted the comparable efficacy and safety of acetaminophen (paracetamol) and ibuprofen in encouraging ductal closure. The closure of the ductus arteriosus is a serious therapeutic intervention for premature infants with hemodynamically significant PDA (hsPDA), and cyclooxygenase (COX) inhibitors like ibuprofen and acetaminophen have long been considered first-line treatments.

Abiding by the PRISMA protocol, this review sifted through recent literature from Medline, PubMed, Latin American and Caribbean Literature on Health Sciences (LILACS), and SciELO, focusing on studies directed between 2013 and 2023. Thereafter, 8 randomized trials involving 781 newborns with PDA were evaluated, comparing the safety and effectiveness of acetaminophen and ibuprofen.

Both were equally effective in facilitating ductus arteriosus closure, with no statistically noteworthy disparities in adverse effect occurrences. This review brings lucidity to clinical decision-making, affirming that both acetaminophen and ibuprofen can be safely used for PDA closure in premature infants. Additional investigation, however, remains critical to refine clinical protocols and optimize treatment strategies.

Source:

Arquivos Brasileiros de Cardiologia

Article:

Therapeutic Efficacy and Safety of Paracetamol versus Ibuprofen in Patent Ductus Arteriosus in Newborns: A Systematic Review

Authors:

Halecy Davidson Sousa da Silva et al.

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