In a recent study conducted by researchers, psychological factors like anxiety, stress, and depression played a fundamental role in anticipating sleep disorders and fatigue among those struggling with multiple sclerosis. The aim of this research was to shed light on the intricate connection between mental health and physical symptoms in multiple sclerosis-affected people. With a sample size of 252 subjects selected through purposive sampling, the study employed various measures including the Depression, Anxiety, and Stress Scale (DASS-21),  Fatigue Severity Scale (FSS), and Mini-Sleep Questionnaire (MSQ) to collect and analyze data. The results revealed a strong positive correlation between sleep disorders and depression (r = 0.56), anxiety (r = 0.52), and stress (r = 0.40), indicating that individuals experiencing higher levels of these psychological factors are more likely to suffer from sleep disturbances.

Age did not exhibit a statistically significant connection with the overall score of sleep disorders (r = -0.001; P < 0.985). However, age showed associations with insomnia (r = -0.146; P < 0.021) and oversleeping (r = 0.153; P < 0.015). There was no profound relationship found between age and fatigue (r = -0.044; P < 0.941). Furthermore, the findings indicated that fatigue in multiple sclerosis patients is markedly related to  anxiety (r = 0.54), stress (r = 0.48), and depression (r = 0.52).

Regression analysis demonstrated that depression, stress, and anxiety collectively forecast a substantial portion of the variance in both sleep disorders (0.37%) and fatigue (0.35%) among multiple sclerosis sufferers. These outcomes emphasize the prominence of addressing psychological well-being in the management of multiple sclerosis-related symptoms. Healthcare professionals may consider incorporating psychological interventions alongside traditional treatments to boost sleep quality and alleviate fatigue in multiple sclerosis patients.