Lipid transfer proteins IgE tests in allergy diagnosis :- Medznat
EN | RU
EN | RU

Help Support

By clicking the "Submit" button, you accept the terms of the User Agreement, including those related to the processing of your personal data. More about data processing in the Policy.
Back

New update in allergology: LTP IgE as a diagnostic aid for food allergies

Food allergy Food allergy
Food allergy Food allergy

What's new?

Peanut and hazelnut allergies can be diagnosed with lipid transfer proteins-specific IgE tests alongside other tools for diagnosis.

Based on 15 prospective, or retrospective cross-sectional studies, totalling 2,395 participants, Ara h 9 (peanut) and Cor a 8 (hazelnut) serum specific immunoglobulin E (sIgE) tests proved to be valuable tools for diagnosing food allergies in patients suspected of reacting to foods containing lipid transfer proteins (LTPs).

This review by Chiara Bellia et al. was published in the ‘International Journal of Molecular Sciences’ and included participants with oral food challenges (both open and double-blind placebo-controlled) as the reference standard. Relevant studies were sourced from Scopus, PubMed, Web of Science, and ClinicalTrial.org, with bias risk assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS)-2 tool.

The sensitivity of Ara h 9 for diagnosing peanut allergies ranged between 6% to 61%, while its specificity fell between 57% and 100%. Likewise, Cor a 8 demonstrated a sensitivity ranging from 11% to 43% and specificity between 59% and 94%. Both sIgE tests may be useful in confirming peanut and hazelnut allergies in symptomatic individuals, but their diagnostic accuracy may be limited by low sensitivity. Further research is needed to define the broader clinical role of sIgE tests in food allergy diagnosis, the authors concluded.

Source:

International Journal of Molecular Sciences

Article:

Diagnostic Accuracy of Lipid Transfer Proteins (LTPs) Specific IgE Assay in Food Allergy: A Systematic Review

Authors:

Chiara Bellia et al.

Comments (0)

You want to delete this comment? Please mention comment Invalid Text Content Text Content cannot me more than 1000 Something Went Wrong Cancel Confirm Confirm Delete Hide Replies View Replies View Replies en ru
Try: