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Renal sympathetic denervation markedly reduces BNP levels while baroreflex activation therapy significantly improves quality of life in patients with heart failure.
A study led by Ping-Tao Tseng et al. has evaluated the potency of various nerve stimulation and modulation strategies for heart failure, offering fresh insights into which approaches might deliver the greatest clinical benefits.
Researchers conducted a systematic review and frequentist network meta-analysis (NMA), pooling data from randomized controlled trials (RCTs) that explored the impact of various nerve-targeted therapies in patients with heart failure. This method allowed them to directly and indirectly compare multiple interventions within a single statistical framework. The study considered both objective clinical measures (such as brain natriuretic peptide [BNP] serum levels, which reflect cardiac stress) and subjective outcomes (including quality of life and psychosocial functioning). Interventions were categorized based on the nervous system targets and whether they included additional vascular components.
Key findings:
These findings suggest that not all nerve modulation approaches are equal, and that targeting the vasculature alongside the autonomic nervous system may be key to achieving meaningful therapeutic outcomes in heart failure patients.
Heart Rhythm
Network meta-analysis on efficacy of nerve stimulation or modulation in patients with heart failure
Ping-Tao Tseng et al.
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