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Analyzing specific microbial features in the upper reproductive tract could revolutionize PCOS diagnosis and treatment, offering a personalized, biomarker-driven approach to women's health.
Could the microbiome be a quintessential part of unlocking better PCOS treatments? A new study in the OXFORD ACADEMIC-Human Reproduction journal showed how reproductive tract microbes may help identify biomarkers that could change the future of diagnosis.
This research led by S Lee, conducted at Oulu University Hospital, Finland, included a total of 83 vaginal swabs and 80 endometrial flushing samples from 52 women with PCOS and 37 healthy controls. The study, which spanned from January 2017 to March 2020, aimed to identify how PCOS, menstrual cycle phases, and ovulatory status influence the microbiome in both the vaginal and uterine environments.
Key findings:
As this is the first study to simultaneously analyze the upper and lower reproductive tract microbiomes, it opens doors for more research into microbiome-based biomarkers. While this study’s sample size limits certain conclusions, the outcomes hold significant promise in understanding and managing PCOS through the lens of the microbiome.
OXFORD ACADEMIC-Human Reproduction
The reproductive tract microbiome in women with polycystic ovary syndrome and across different menstrual cycle phases
S Lee et al.
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