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Diclofenac potassium achieves superior control of post-extraction pain at 36 hours compared with loxoprofen sodium, with a higher proportion of patients reporting no or mild pain, independent of gender and extraction type.
According to the outcomes of a triple-blind randomized clinical trial from Saudi Arabia, diclofenac potassium offers marginally better control of pain following tooth extraction than loxoprofen sodium, regardless of patient gender or the type of dental extraction performed.
Pain is among the most frequent complications after tooth extraction, and nonsteroidal anti-inflammatory drugs (NSAIDs) such as loxoprofen sodium and diclofenac potassium are routinely prescribed. However, comparative evidence across genders and extraction types has been limited. To address this gap, investigators enrolled 100 male and female patients undergoing either simple or surgical tooth extraction.
Volunteers were evenly randomized to receive either loxoprofen sodium or diclofenac potassium, and all patients completed the follow-up period. Post-operative pain was self-reported utilizing the verbal descriptor scale—ranging from “no pain” to varying degrees of discomfort—at 6 hours after extraction and then every 12 hours for 3 consecutive days. Data were examined through descriptive statistics and chi-square testing.
At 36 hours post-extraction, those in the diclofenac potassium group were considerably more likely to report “no pain” or “mild pain” compared with those receiving loxoprofen sodium (86% vs. 66%). This difference was noted irrespective of patient gender or whether the extraction was simple or surgical. At all other assessed time points, pain relief was similar between the two groups, with no vital differences (p > 0.05).
Overall, both analgesics were beneficial in tackling post-operative dental pain, but diclofenac potassium illustrated a modest advantage at the 36-hour mark. The findings suggest that while either drug may be appropriate for routine pain care after tooth extraction, diclofenac potassium may offer slightly superior pain control during the early post-operative period.
Dentistry Journal
Loxoprofen Sodium Versus Diclofenac Potassium for Post-Dental Extraction Pain Relief: A Randomized, Triple-Blind, Clinical Trial
Ibrahim Nourwali et al.
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