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A routine blood-derived inflammatory marker helps identify acute pancreatitis patients who face a higher risk of organ failure and in-hospital death.
Acute pancreatitis presents with an unpredictable clinical course, ranging from mild self-limiting disease to life-threatening systemic complications. Clinicians increasingly seek rapid, cost-effective tools to identify high-risk patients soon after hospital presentation. A simple blood-based marker, the neutrophil-to-lymphocyte ratio (NLR), is emerging as a useful tool for the early identification of patients at increased risk of complications.
Researchers examined the ability of admission NLR to identify patients at increased risk of persistent organ failure and mortality associated with acute pancreatitis. A systematic review and meta-analysis were conducted on studies reporting NLR measurements obtained at hospital admission in acute pancreatitis. The studies were retrieved from PubMed, Scopus, and Google Scholar up to September 2025, with further records identified through manual examination of reference lists. Data from eligible studies were pooled using random-effects statistical models, while diagnostic accuracy was assessed through hierarchical summary receiver operating characteristic analyses.
A total of 23 eligible investigations were analyzed.
The analysis supported the role of admission NLR as an effective early warning indicator in acute pancreatitis. While it was not intended to replace established prognostic models, it offered additional value because of its simplicity, availability, and reproducibility. The authors highlighted that combining NLR with clinical assessment and conventional laboratory parameters could improve early risk stratification and assist clinicians in prioritizing care for patients most vulnerable to severe disease progression.
EMERGENCY MEDICINE
Two сells, one signal: neutrophil-to-lymphocyte ratio as a risk beacon in acute pancreatitis (systematic review & meta-analysis)
S.M. Chooklin et al.
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