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Single-cell technologies now uncover microbe-specific immune signatures in pulpitis, advancing biomarker-guided diagnosis and enabling highly precise, personalized vital pulp therapy.
Pulpitis remains a complex, microbially driven inflammatory condition with unpredictable progression. The absence of reliable biological markers forces reliance on subjective diagnosis, limiting precision in vital pulp therapy. This study systematically evaluated the microbial landscape and identified key microbial with host-derived biomarkers to enable objective disease assessment and improved clinical decision-making.
Researchers executed a comprehensive review of existing literature emphasizing on microorganisms implicated in pulpitis and their pathogenic mechanisms. Host responses, particularly those of dental pulp stem cells (DPSCs), were systematically analyzed across different microbial exposures. Reported biomarker candidates from multiple studies were compiled and evaluated. Additionally, single-cell transcriptomic data were integrated to validate infection-specific cellular responses and to enhance the resolution of host–microbe interaction analysis.
The findings demonstrated that:
In conclusion, microbial- and host-derived biomarkers have strong translational potential for stratifying pulpitis severity, guiding vital pulp therapy decisions, and predicting treatment outcomes. Integration of microbial characterization with DPSC response profiling, supported by single-cell transcriptomics, may advance toward more objective detection and personalized pulpitis management.
Journal of Oral Microbiology
Pulpitis as a microbial disease: single-cell insights into host responses and diagnostic biomarkers for vital pulp therapy
Tiansong Xu et al.
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