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Bee allergy significantly correlates with higher H. pylori infection rates and increased gastric inflammation.
A new retrospective study suggests a potential link between bee allergy and elevated gastric mucosal inflammation, along with a higher prevalence of Helicobacter pylori (H. pylori) infection in individuals experiencing dyspeptic symptoms.
Researchers analyzed medical records of 58 people who underwent upper gastrointestinal (GI) endoscopy. The study group included 29 individuals with self-reported bee allergy, matched with 29 controls based on age, gender, and GI complaints. Antral biopsy samples were assessed for histopathological features, including chronic inflammation, neutrophil activity, H. pylori presence, atrophy, intestinal metaplasia, and dysplasia.
Higher Inflammation and Infection Rates Observed
Findings revealed that bee allergy-affected people had noticeably increased neutrophil activity, higher rates of chronic gastric inflammation, and greater H. pylori positivity compared to controls. These results indicate a notable connection between allergic status and gastric mucosal immune response. Path analysis further supported these observations, showing that bee allergy was positively linked with:
Electrolyte Differences but Stable Blood Markers
While most hematological, biochemical, and coagulation parameters were comparable between groups, bee allergy-affected people showed noticeably elevated sodium and potassium levels. These electrolyte variations may suggest broader systemic effects linked with allergic ailments.
Clinical Implications
The study highlights a possible interplay between allergic responses and GI inflammation. Although causality cannot be established due to the retrospective design, the findings raise important questions about immune-mediated mechanisms linking bee allergy with gastric pathology.
Further prospective and mechanistic studies are needed to clarify whether bee allergy directly contributes to heightened susceptibility to H. pylori infection or chronic gastric inflammation, and to explore potential implications for patient management.
Medicine (Baltimore)
Association between bee allergy and gastric inflammation: A retrospective study of Helicobacter pylori and mucosal findings
Berkan Acar et al.
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