The goal of a double-blinded, randomized, placebo-controlled trial was to examine the clinical benefits of high tibial osteotomy (HTO) and platelet-rich plasma (PRP) combination for osteoarthritis of the knee.

Participants were allocated into three groups at random using computer-derived random charts: HTO + PRP was given to 24 subjects in group A (24 knees), HTO + hyaluronic acid was given to 25 subjects in group B (25 knees), and HTO + normal saline (physiological control/placebo) was given to 25 subjects in group C (25 knees).

Preoperatively and at the last follow-up, the visual analogue scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were determined. The presence of newly produced cartilaginous tissue and International Cartilage Repair Society grade were used to determine the status of the articular cartilage during an arthroscopy. The cartilage thickness in knee joint was measured using magnetic resonance imaging.

The final follow-up findings of knee function in Group A such as total WOMAC score and VAS score were substantially distinct from Group B and C. All patients in Group A had femur and tibial cartilage regeneration. The cartilaginous thickness of posterior condyle region, posterior meniscal region, anterior meniscal region, and anterior patella femoral region in Group A were substantially different from those of groups B and C (Table 1).

For relieving knee pain and slowing the advancement of medial knee osteoarthritis, treatment with HTO and PRP may be a more reasonable option.