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Ovulation induction stands as the cornerstone of infertility care in women with polycystic ovarian syndrome (PCOS). While clomiphene citrate has traditionally been the agent of choice, letrozole has emerged as a preferred alternative due to its higher ovulation rates.
Co-administration of N-acetylcysteine with letrozole offers a promising strategy to boost ovulation and improve pregnancy success in women struggling with PCOS-related infertility.
Ovulation induction stands as the cornerstone of infertility care in women with polycystic ovarian syndrome (PCOS). While clomiphene citrate has traditionally been the agent of choice, letrozole has emerged as a preferred alternative due to its higher ovulation rates. Hence, this study investigated whether combining N-acetylcysteine (NAC) with letrozole can further enhance ovulation and pregnancy outcomes in PCOS-related infertility.
In this randomized clinical trial, PCOS patients were randomized to receive either letrozole + NAC or letrozole + placebo.
Follicular development, ovulation, and pregnancy success were more pronounced in the letrozole + NAC group when compared to letrozole + placebo group, as shown in Table 1:
Letrozole + NAC increased follicle size, ovulation induction, and pregnancy success when compared to the letrozole + placebo in infertile PCOS patients.
Journal of Obstetrics, Gynecology and Cancer Research
Combination of N-Acetylcysteine and Letrozole in Induction of Ovulation for infertile women with polycystic ovarian syndrome
Aubead NM
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