Probiotic combinations improve blood sugar management in type 2 diabetes :- Medznat
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Multistrain probiotics offer better glycemic control in type 2 diabetes

Type 2 diabetes mellitus Type 2 diabetes mellitus
Type 2 diabetes mellitus Type 2 diabetes mellitus

What's new?

Multistrain probiotic combinations show greater glycemic control than single strains, with Lactobacillus + Bifidobacterium + Streptococcus emerging as a promising option for managing type 2 diabetes.

Type 2 diabetes mellitus (T2DM), a chronic ailment affecting millions worldwide, continues to strain healthcare systems with rising prevalence and complex management. While medications, lifestyle changes, and dietary modifications remain the cornerstone of treatment, researchers are increasingly turning their attention to the role of gut health in blood sugar regulation.

A recent network meta-analysis (NMA), published following a comprehensive review of randomized controlled trials (RCTs), suggests that multi-strain probiotic therapy could offer significant benefits for blood sugar control in patients with T2DM. Researchers conducted a systematic review across four major medical databases — PubMed, Embase, Web of Science, and the Cochrane Library — to identify trials involving probiotics in T2DM.

The analysis included 30 RCTs, encompassing 1,861 volunteers, and compared the effects of different probiotic strains and combinations on key diabetes-related outcomes. Using a robust Bayesian network meta-analysis, the team ranked each probiotic intervention based on its effectiveness in improving four key glycemic indicators:

  • Fasting plasma glucose
  • Glycated hemoglobin A1c (HbA1c)
  • Insulin resistance (measured via homeostatic model assessment of insulin resistance [HOMA-IR])
  • Insulin secretion

The results revealed not all probiotics are created equal — and multi-strain combinations outperformed single-strain formulations in most areas of diabetes management.

  • The combination of Lactobacillus (LAC) + Bifidobacterium (BIF) + Propionibacterium (PRO) + Streptococcus (STR) illustrated the most significant decrease in fasting plasma glucose and improvement in insulin resistance, with surface under the cumulative ranking (SUCRA) scores of 88.8% and 77.3%, respectively.
  • For minimizing HbA1c, which reflects average blood glucose levels over 2–3 months, BIF alone exhibited the most potent effect (SUCRA: 93.1%).
  • When it came to enhancing insulin secretion, the pairing of LAC and BIF was most effective (SUCRA: 84.7%).

A cluster analysis of all four outcome measures indicated that the LAC + BIF + STR combination may offer the most comprehensive glycemic benefit, making it a promising candidate for clinical application. While not a replacement for conventional treatment, probiotics could soon become a valuable component of holistic diabetes care.

Source:

Nutrition Research

Article:

Probiotic supplementation contributes to glycemic control in adults with type 2 diabetes: A systematic review and network meta-analysis

Authors:

Dengrong Ma et al.

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