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Loxoprofen significantly reduces lumbar pain in elderly patients with minimal side effects.
A large multicentre study involving more than 4,000 elderly patients found that loxoprofen sodium offered meaningful relief from lumbar pain while maintaining a favorable safety profile.
The open-label trial, published in Drug Investigation, included 4,024 patients with a mean age of 72.5 years who were experiencing lumbar pain linked to various rheumatic disorders. Participants received loxoprofen sodium 180 mg daily, given as 60 mg three times a day, for up to 8 weeks.
Researchers observed rapid and clinically remarkable improvements, particularly among those with less severe pain. After 4 weeks of treatment, subjective symptom improvement reached 83% in those with mild-to-moderate lumbar pain. Improvement rates were 30% in those with moderate-to-severe pain and 24% in patients with severe pain
Notably, patients with mild-to-moderate pain experienced significant objective and subjective improvement within just 1 week of starting therapy. Across all pain severity categories, notable benefits became evident by week 4. The treatment also illustrated strong tolerability in this elderly population. Adverse events were noted in only 2.2% of patients, with most side effects described as mild and primarily involving the gastrointestinal tract.
The findings suggest that loxoprofen may offer an effective and well-tolerated nonsteroidal anti-inflammatory drug (NSAID) treatment option for elderly patients with lumbar pain, delivering early symptom relief with a low incidence of adverse effects.
Drug Investigation
Effectiveness and Safety of Loxoprofen in Elderly Patients with Lumbar Pain
T. Aoki
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