Categories
Change Password!
Reset Password!
Among elderly patients scheduled for noncardiac surgery, perioperative use of low-dose intravenous ketorolac does not increase the risk of post-surgery acute kidney injury.
Concerns surrounding nonsteroidal anti-inflammatory drugs (NSAIDs), particularly ketorolac, and their potential to trigger acute kidney injury (AKI) in older adults may be overstated in the perioperative setting, according to a large retrospective cohort study.
Investigators evaluated 27,106 patients aged ≥60 years who underwent noncardiac surgery lasting ≥1 hour and needed hospitalization beyond 2 days.
Postoperative AKI within 7 days occurred less frequently in those receiving ketorolac when compared to those not receiving it (Table 1).
The findings of adjusted risk analysis (after 1:3 propensity score matching) are depicted below (Table 2):
Consistency Across Analyses
In elderly patients undergoing noncardiac surgery, a single low-dose (30 mg) intravenous ketorolac regimen appears renal-safe, supporting its use as a valuable option for immediate postoperative pain management without increasing AKI risk.
Scientific Reports
Perioperative ketorolac use and postoperative acute kidney injury in elderly patients undergoing noncardiac surgery: a retrospective cohort study
Ah Ran Oh et al.
Comments (0)