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Specific itch sensations in atopic dermatitis are associated with different inflammatory biomarkers, with crawling linked to IL-31 and stinging/stabbing linked to TARC.
Atopic dermatitis (AD) remains a chronic inflammatory skin disorder characterized by persistent itching that significantly affects patients' quality of life. Although itch is one of the hallmark symptoms of the disease, emerging evidence suggests that cytokines and chemokines may influence how patients perceive itch sensations, potentially offering new insight into disease mechanisms and symptom evaluation. This study aimed to investigate the relationship between multiple itch qualities, circulating blood biomarkers, patient-reported outcome measures (PROMs), and clinical disease severity in adult Japanese patients with AD.
Researchers evaluated 10 distinct itch qualities in adult Japanese patients with AD using a translated standardized questionnaire. Associations were analyzed between individual itch sensations and several blood biomarkers, including interleukin-31 (IL-31), thymus and activation-regulated chemokine (TARC), lactate dehydrogenase, eosinophil, basophil, and neutrophil counts, as well as total immunoglobulin E levels (IgE). The study also assessed correlations with PROMs such as the visual analog scale (VAS) and patient-oriented eczema measure, alongside objective clinical assessments including the eczema area and severity index.
The results demonstrated:
The findings indicated that itch sensations in Japanese patients with AD could be categorized into biologically distinct patterns associated with different inflammatory pathways. Crawling-type itch appeared to be linked primarily to IL-31 activity, whereas stinging and stabbing sensations were more closely related to TARC-mediated inflammation.
Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Differences in Itch Quality Between Interleukin-31 and Thymus and Activation-Regulated Chemokine of Japanese Atopic Dermatitis
Yozo Ishiuji et al.
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