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Perioperative ovarian PRP use preserves AMH levels, supports ovarian regeneration, and improves sexual function outcomes in women aged 35–50 undergoing hysterectomy for benign disease.
In women aged 35–50 years, declining ovarian reserve—reflected by reduced anti-Müllerian hormone (AMH) levels—poses substantial reproductive and hormonal challenges. Even when ovaries are conserved during hysterectomy for benign conditions such as abnormal uterine bleeding and leiomyomas, many women experience accelerated ovarian aging and menopausal symptoms that negatively affect sexual health and quality of life.
A recent observational case-control study led by Ayşe Betül Albayrak et al. evaluated whether perioperative ovarian platelet-rich plasma (PRP) therapy could mitigate postoperative ovarian decline and sexual dysfunction. The study included women aged 35–50 who underwent hysterectomy for benign disease and were segregated into two groups:
Researchers compared preoperative AMH levels and female sexual function index (FSFI) scores with those measured three months after surgery. Postoperative AMH levels declined considerably in the control group (p < 0.001), confirming accelerated ovarian reserve reduction after hysterectomy. In contrast, the PRP group illustrated a slight postoperative increase in AMH, with a statistically significant difference between pre- and postoperative levels (p = 0.0001).
Sexual function outcomes were also superior in the PRP group. Total FSFI scores were higher compared with controls. Subdomain analysis showed notable improvements in lubrication, orgasm, satisfaction, and pain. Within the PRP group, significant pre- to postoperative improvements were witnessed in orgasm, pleasure, and pain scores.
These findings indicate that perioperative ovarian PRP may support ovarian regeneration, preserve AMH levels, and enhance postoperative sexual function in those undergoing uterus removal surgery for benign indications. Although benefits appear modest, the results emphasize PRP as a valuable regenerative strategy that warrants standardized treatment protocols and larger, controlled trials.
Ginekologia Polska
Effect of intraovarian Platelet Rich Plasma injection during hysterectomy on ovarian reserve and sexual life
Ayşe Betül Albayrak et al.
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