Categories
Change Password!
Reset Password!
Impulse dyscontrol symptoms correlate with CSF amyloid-beta levels in patients with subjective cognitive decline and mild cognitive impairment.
A new Brazilian cross-sectional study has found a significant association between impulse dyscontrol symptoms and amyloid-beta pathology in people with subjective cognitive decline (SCD) and mild cognitive impairment (MCI), supporting growing evidence that neuropsychiatric symptoms may emerge during the early stages of Alzheimer’s disease (AD).
Researchers investigated the link between neuropsychiatric symptoms and cerebrospinal fluid (CSF) biomarkers of AD in individuals experiencing early cognitive changes but not dementia. The study included 71 Brazilian participants, including 54 patients with MCI and 17 with SCD. Eligible participants were aged 55 years or older, had cognitive complaints, and completed comprehensive medical and neuropsychological evaluations.
Individuals with dementia, significant psychiatric or neurological disorders, traumatic brain injury, substance abuse, or severe white matter changes were excluded. Investigators assessed neuropsychiatric symptoms using the Mild Behavioral Impairment Checklist (MBI-C) and analyzed CSF Alzheimer’s biomarkers, including amyloid-beta peptide levels. The analysis revealed a statistically significant correlation between domain C of the MBI-C—which evaluates impulse dyscontrol symptoms—and CSF amyloid-beta concentrations.
According to the researchers, the findings strengthen the hypothesis that impulsivity-related behavioral symptoms may be linked to underlying amyloid pathology even before dementia develops. The study highlights the potential importance of monitoring behavioral and psychiatric symptoms in patients with early cognitive decline.
The authors emphasized that further studies are needed to better clarify the connection between mild behavioral impairment, neuropsychiatric symptoms, and AD biomarkers in the pre-dementia stages of the disease.
Psychogeriatrics
Impulse Dyscontrol Symptoms Are Related to Amyloid Beta in Patients With Subjective Cognitive Decline and Mild Cognitive Impairment
Ana Luiza Gonçalves Rochetti et al.
Comments (0)