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Folic acid, probiotics, vitamin C, vitamin E, curcumin, and DKB114 significantly reduce uric acid, oxidative stress, and LDL cholesterol in patients with hyperuricemia and gout.
According to a large-scale analysis of 30 clinical trials involving 44,972 patients, certain dietary supplements can remarkably boost metabolic health in patients with hyperuricemia and gout.
Researchers reviewed randomized controlled trials published in both English and Chinese databases. Using network meta-analysis (Stata 16.0) and quality assessment tools (RevMan 5.3), they compared the impact of dietary supplements on uric acid regulation, oxidative stress, and lipid metabolism.
Key findings
No serious safety concerns were reported across the included supplements. The findings suggest that targeted dietary supplements may serve as effective adjunct therapies for patients with gout and hyperuricemia, supporting not just uric acid control but also oxidative and lipid balance. The authors recommend larger, long-term studies to confirm these benefits and guide clinical use.
Nutrition and Metabolism
The effectiveness and safety of specific dietary supplements in modulating uric acid levels, oxidative stress, and lipid metabolism in patients: a network meta-analysis of 13 interventions
Guancheng Ye et al.
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