A retrospective propensity score matching analysis was carried out to determine the safety and efficacy of HDDT 10-day vs 14-day and explore the factors that may influence the helicobacter pylori (H. pylori) elimination rates.

In this analysis ascertaining if HDDT with distinct regimens leads to different elimination rates, the participants were allocated to either a 10-day HDDT group or a 14-day HDDT group (20 mg esomeprazole and 750 mg amoxicillin, given 4 times daily). Comparison of the elimination rates, CYP2C19 gene polymorphisms, patient compliance, antibiotic resistance rates, and adverse events were done.

The elimination rate as per intention to treat (ITT) and per-protocol (PP) analysis, and  drug-related adverse events is shown in Table 1:

No profound differences were witnessed between the compliance rates of the groups. The CYP2C19 gene polymorphism did not influence the elimination rates of the groups.

The 14-day HDDT can be preferred over the 10-day HDDT in patients with H. pylori infection.