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Infants with cow’s milk protein allergy experience marked digestive symptom relief with extensively hydrolyzed and rice-based formulas in primary care practice.
Cow’s milk protein allergy (CMPA) emerges early in life as a frequent cause of gastrointestinal distress, often disrupting feeding patterns and hindering optimal growth, thereby making nutritional therapy a core component of management strategies. Within this clinical landscape, the study set out to explore the real-world application and therapeutic value of extensively hydrolyzed formulas (eHF) and hydrolyzed rice formulas (HRF), specifically examining their potency in alleviating digestive symptoms in infants managed in primary care settings.
A national, multicenter, ecological descriptive study (NOVA-ALLERGY) was carried out in pediatric primary care settings across Spain, enrolling 300 clinicians from pediatrics and family medicine. Data were obtained through a structured questionnaire documenting clinicians’ experience with their six most recent infants diagnosed or suspected of CMPA and treated with eHF or HRF. The study evaluated management strategies, patient characteristics, and alterations in clinical symptoms over the follow-up period.
The results revealed that infants initiated on eHF or HRF were predominantly aged 0–6 months and presented with mild-to-moderate CMPA, with gastrointestinal symptoms as the primary manifestation. At follow-up, a clear and consistent clinical improvement was observed, with marked reductions across a broad range of digestive symptoms such as blood in stools, refusal to eat, difficulty swallowing, loose stools, vomiting, infantile colic, bloating, or recurrent regurgitation.
These findings validate guideline-recommended use of eHF for CMPA while supporting HRF as an effective alternative. Both interventions demonstrated consistent gastrointestinal symptom improvement, reinforcing their role in routine clinical practice.
Atención Primaria
[Clinical experience on the use of formulas for cow's milk protein allergy in Pediatric consultations]
Carolina Rubio-Jovani et al.
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