According to a review issued in ‘Clinical, Cosmetic and Investigational Dermatology’, the use of Emollients Plus may not only serve as a potent maintenance therapy for atopic dermatitis (AD) patients, but also when used synergistically with anti-inflammatory treatments. Emollients have been the cornerstone for maintaining AD. A new class of emollients, known as 'Emollients Plus,' incorporating active, non-medicated elements (such as saponins, riboflavins, flavonoids from extracts of protein-free oat plantlet, along with bacterium lysates), has created a distinction that blurs the traditional lines between emollients and topical medications.

Based on literature searches and author expertise, the relevant keywords and research articles were deduced from the PubMed database. While the definition of an ideal emollient includes five components, no unanimous consensus exists for 'Emollients Plus.' These formulations exhibit significant diversity in composition and modes of action for AD treatment, potentially influencing their clinical effectiveness.

Various treatment approaches for AD have been proposed, encompassing preventive, proactive, intermittent, and synergistic methods. The effectiveness of Emollients Plus in improving the damaged skin barrier function has been validated across various dimensions. Their impact on epidermal barriers (physical and biochemical, immunological, neuro-sensory and microbial) has been confirmed by pieces of evidence. When deciding on AD treatment, the safety of available topical therapies needs to be assessed.