Effect of L-carnitine on anthropometric and malnutrition status in stroke patients :- Medznat
EN | RU
EN | RU

Help Support

By clicking the "Submit" button, you accept the terms of the User Agreement, including those related to the processing of your personal data. More about data processing in the Policy.
Back

Can early L-carnitine combat malnutrition in stroke patients?

Acute ischemic stroke Acute ischemic stroke
Acute ischemic stroke Acute ischemic stroke

What's new?

L-carnitine effectively counteracts muscle wasting, reduces weight and anthropometric declines, improves serum albumin levels, and lowers malnutrition risk in acute ischemic stroke patients.

A new study issued in "BMC Nutrition" suggests that early L-carnitine supplementation could help prevent malnutrition and muscle wasting in patients recovering from acute ischemic stroke. Malnutrition is a major concern in stroke rehabilitation, often leading to poor recovery outcomes and reduced independence. Researchers conducted a randomized, placebo-controlled trial to examine whether L-carnitine could mitigate the catabolic effects of stroke.

In this study, 82 patients experiencing their first ischemic stroke were randomly allocated to get either 1000 mg L-carnitine (3 times daily for 7 days) or a placebo. Using an intention-to-treat approach, the study monitored alteration in weight, body mass index, triceps skinfold thickness, mid-arm circumference, mid-arm muscle circumference, arm muscle area, calf circumference, serum albumin levels, and malnutrition status throughout the intervention period. Based on serum albumin concentration, triceps skinfold thickness, and mid-arm muscle circumference, malnutrition was assessed.

Between-group differences were analyzed via analysis of covariance (ANCOVA), adjusting for baseline mean values. As found, those receiving L-carnitine experienced markedly less weight loss and muscle deterioration as opposed to the placebo group. The supplementation helped maintain mid-arm circumference, body mass index, calf circumference, and triceps skinfold thickness, indicating better nutritional status. Notably, the L-carnitine group exhibited a higher serum albumin concentration, suggesting improved protein metabolism and reduced malnutrition risk.

By the end of the study, 41.5% of L-carnitine patients remained malnourished, compared to 73.2% in the placebo group. Additionally, recovery rates were substantially higher in the L-carnitine group, with 43.9% showing improvement versus just 7.3% in the placebo group. These findings highlight L-carnitine’s potential as a supportive nutritional therapy for stroke sufferers, particularly in the early stages of recovery. By minimizing muscle loss and stabilizing nutritional markers, L-carnitine may boost rehabilitation outcomes, offering a simple yet efficient intervention for stroke patients at risk of malnutrition.

Source:

BMC Nutrition

Article:

The effect of L-carnitine supplementation on anthropometric and malnutrition status in acute ischemic stroke patients: a triple-blinded randomized clinical trial

Authors:

Samaneh Hajjarzadeh et al.

Comments (0)

You want to delete this comment? Please mention comment Invalid Text Content Text Content cannot me more than 1000 Something Went Wrong Cancel Confirm Confirm Delete Hide Replies View Replies View Replies en ru
Try: