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Helicobacter pylori (H. pylori), a well-known cause of peptic ulcers, triggers long-term systemic inflammation.
H. pylori infection increases the risk of developing COPD and asthma, independent of smoking status.
Helicobacter pylori (H. pylori), a well-known cause of peptic ulcers, triggers long-term systemic inflammation. Chronic obstructive pulmonary disease (COPD) and asthma are also driven by inflammatory mechanisms in the airways. This study evaluated whether H. pylori infection elevates the risk of developing COPD or asthma in a nationwide Korean cohort.
The researchers retrieved data from the Korean National Health Insurance Database for adults ≥40 years who received H. pylori elimination therapy.
Among those with H. pylori infection, COPD and asthma incidence rates were 10.92 and 15.99 per 1,000 person-years, respectively. H. pylori infection was linked to a significantly increased risk of COPD and asthma (aHR 1.17, 95% CI 1.12–1.22), independent of smoking status (Table 1).
COPD risk surged most prominently among adults ≥65 years and current smokers, whereas asthma risk remained uniformly elevated across demographic and smoking subgroups.
People infected with H. pylori were more likely to develop COPD and asthma. While asthma risk was stable across demographic and lifestyle factors, COPD risk varied by age and smoking. These results highlight a potential inflammatory link between gastric H. pylori infection and respiratory diseases.
Gut Pathogens
Helicobacter pylori infection is associated with an increased risk of chronic obstructive pulmonary disease and asthma
Chiwook Chung et al.
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