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Boric acid, when used as an adjunct to non-surgical periodontal therapy, can successfully improve clinical parameters (particularly probing pocket depth and clinical attachment level) in periodontitis.
As per the outcomes of a study led by Reham Abdel-Fatah et al., subgingival boric acid application alongside non-surgical periodontal therapy may boost long-term clinical outcomes in periodontitis-affected individuals. In this systematic review and meta-analysis, the goal was to investigate the therapeutic potential of boric acid as a local drug delivery agent in periodontitis.
Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, researchers reviewed randomized controlled trials (RCTs) that examined the effects of subgingival boric acid irrigation alongside non-surgical periodontal care. Probing pocket depth (PPD), clinical attachment level (CAL), and gingival index (GI) were examined. Out of 1,640 screened records, only 6 studies fulfilled the inclusion criteria, encompassing 281 volunteers aged 18 to 65 years.
At the 1-month mark, boric acid led to a notable reduction in PPD, though changes in CAL and GI remained negligible. However, as time progressed, the benefits became more pronounced—PPD portrayed remarkable improvement at 3 and 6 months, and by the 6-month follow-up, CAL gains became statistically significant in favor of boric acid. However, GI remained unaltered throughout the study period.
The findings highlight boric acid’s potential in fostering periodontal therapy outcomes, particularly in reducing PPD and improving CAL over time. While boric acid did not offer immediate clinical benefits, its long-term impact on periodontal health was significant. Thus, it presents a viable addition to gum health care, particularly in those with inadequate responses to standard therapy or a heightened risk of progression. Its cost-effectiveness and favorable safety profile further enhance its appeal, making it a practical option, especially in resource-constrained settings.
BMC Oral Health
Therapeutic potential of boric acid as a local drug delivery agent in periodontitis: a comprehensive systematic review and meta-analysis
Reham Abdel-Fatah et al.
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