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Chronic hepatitis B virus (HBV) affects millions worldwide, contributing to 9,00,000 deaths annually from cirrhosis and liver cancer (hepatocellular carcinoma).
Tenofovir disoproxil fumarate effectively reduces mother-to-child transmission of the hepatitis B virus, supporting its role in maternal health programs.
Chronic hepatitis B virus (HBV) affects millions worldwide, contributing to 9,00,000 deaths annually from cirrhosis and liver cancer (hepatocellular carcinoma). Mother-to-child transmission (MTCT) persists as a major risk, with conventional birth-dose vaccines and hepatitis B immunoglobulin (HBIG) sometimes inadequate for mothers carrying high viral loads. Hence, a systematic review and meta-analysis was conducted to assess the effectiveness of tenofovir disoproxil fumarate (TDF) in preventing MTCT of HBV in pregnant women.
An extensive literature search was executed across PubMed, Embase, and the Cochrane Library. Only randomized controlled trials (RCTs) involving pregnant women with HBV were included, with study quality evaluated using the adapted Newcastle–Ottawa Scale. Pooled effect sizes were estimated by using the DerSimonian and Laird random-effects model, while heterogeneity was assessed via Cochran’s Q and I² statistics.
Out of 1,909 records screened, 160 studies met the inclusion criteria, with 43 specifically evaluating TDF’s potency in preventing HBV in MTCT. Pooled analysis portrayed a remarkable reduction in transmission compared to controls (OR = 0.38), despite moderate heterogeneity (I² = 52.5%). Subgroup analyses by trimester confirmed consistent efficacy with no heterogeneity (I² = 0%). Studies assessing HBV DNA levels also exhibited substantial transmission reduction (OR = 0.25), though heterogeneity was high (I² = 80.94%).
TDF successfully reduces MTCT of HBV, demonstrating consistent efficacy across trimesters. These findings support its integration into maternal health programs. Additional research is required to refine therapeutic protocols and refine preventive strategies for high-risk populations
Innovative Journal of Pediatrics
Tenofovir Disoproxil Fumarate Prevents Mother-to-Child Transmission of Hepatitis B Virus: A Comprehensive Assessment from the Systematic Review and Meta-Analysis
Yan Li et al.
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