Efficacy of loxoprofen sodium + sodium hyaluronate for osteoarthritis pain relief

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Created On: 22/05/2026

This study investigated whether loxoprofen sodium + sodium hyaluronate offers superior therapeutic benefit in osteoarthritis (OA) and also assessed its effect on knee joint function and symptom control.

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Key take away

Combination therapy with loxoprofen sodium and sodium hyaluronate improves knee function, reduces pain, and enhances blood rheology in osteoarthritis patients.

Background

Method

Overall, 98 patients with OA were enrolled and divided into two groups: a control group (n = 51) receiving loxoprofen sodium alone and a study group (n = 47) receiving loxoprofen sodium + sodium hyaluronate. Outcomes assessed included inflammatory markers, Lysholm knee score, visual analog scale (VAS) pain score, Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index, overall treatment efficacy, oxidative stress parameters (malondialdehyde, nitric oxide, superoxide dismutase [SOD]), bone turnover markers, hemorheological indices, and safety outcomes.

Result

Patients receiving the combination therapy illustrated a more favorable biochemical and clinical profile. The study group showed elevated SOD levels along with higher bone-specific alkaline phosphatase and bone gla protein when compared to the control group (p < 0.05), indicating improved oxidative balance and bone metabolism. In contrast, tartrate-resistant acid phosphatase 5b (TRACP-5b) and blood rheology indices were notably reduced in the study group (p < 0.05), reflecting a better joint environment and circulation. Importantly, adverse reaction rates remained comparable between both groups (p > 0.05), suggesting similar safety profiles.

Conclusion

The addition of sodium hyaluronate to loxoprofen sodium delivered enhanced clinical and biochemical benefits in OA management, improving knee function, reducing pain-related burden, and optimizing joint health without compromising safety. These findings support its potential as a more potent therapeutic strategy, though further large-scale validation is warranted.