Osteoporosis is defined as a widespread skeletal condition distinguished by reduced bone strength, low bone mass, altered macro geometry, and micro architectural deterioration of bone tissue. It was first identified from a histological diagnosis but further alterations in mechanical properties was observed due to reductions in both quality and quantity of bone. This condition increases the risk of fractures due to increased porosity & reduced strength. It is the most common bone disease that significantly increases health care costs.
Expert Drug Opinion
15 min read
Pain has always been the major reason for primary care consultations. It signifies that something going inside the body is not right. Chronic pain results in, if acute pain is left untreated for considerable period. Pharmacological management is importantfor controlling any sort of pain. Non-steroidal anti-inflammatory drugs (NSAIDs) are very commonly used for acute pain treatment. Their primary mode of action is the COX inhibition, due to which they also exert dose dependent side effects.
10 min read
The study objective was to assess the efficacy and patient acceptance of ketorolac as an alternative to meperidine for the treatment of severe musculoskeletal low back pain (LBP). A double blinded prospective trial in a convenience sample of patients G18 years of age presenting to an urban university hospital emergency department (ED) was conducted over a 19-month period. Patients were included if the pain was musculo- skeletal in origin and was severe enough to warrant parenteral analgesics. Patients were randomized to receive 1 mg/kg meperidine intramuscularly (IM) or 60 mg ketorolac IM.
Postoperative pain control is essential for achieving optimal patient outcomes. Opioid pain medications, which are often used for postoperative pain control, have deleterious side effects (nausea and vomiting), which limit the effectiveness of these medications. Ketorolac is an attractive alternative for achieving pain control postoperatively; however, concerns over postoperative bleeding have limited its use in clinical practice.
7 min read
Moderate-to-severe acute pain occurs commonly following ambulatory procedures and in patients following surgery. Controlling moderate-to-severe acute pain adequately in the emergency room setting is also a challenge. Conventionally, the central acting opiates have been the keystone of postoperative analgesia; however, the adverse effect profile of opiates, such as respiratory depression, psychomotor disturbances, ataxia, sedation, constipation, tolerance, and dependence, has led some clinicians to avoid repeated dosing of opioids.
6 min read
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