Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and meta-analysis

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Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and meta-analysis
Key Take-Away: 

Previous studies presented limited evidence for the occurrence of mortality in patients with chronic widespread pain (CWP). This study results affirmed that individuals with CWP experience excess mortality. For which the adverse lifestyle factors may be a culprit. Thus for management of CWG lifestyle modifications could be adopted.

Introduction:

It is not clear whether individuals with widespread chronic pain (CWP) undergo premature mortality. This study investigated whether the correlation exists, also estimated its magnitude and discovered what factors interfere with the connection.

 

Methods:

A cohort analysis was conducted comprising 0.5 million individuals of 40-69 years old that hired everywhere from Great Britain in 2006-2010. As compared to the individuals without chronic pain, patients with pain exhibited 'pain all over the body' for >3 months. Data on death (with cause) was present until mid-2015. To determine a pooled estimate of excess risk these results along with other published articles were incorporated in a meta-analysis.

 

Results:

The CWP experienced by a total of seven thousand one hundred thirty participants with excess mortality. Particular conditions of death in excess were cancer, respirator,y cardiovascular, and other disease-associated causes. Excess risk was considerably decreased after adjustment for high body mass index, low levels of physical activity, smoking, and poor quality diet. All studies revealed notable excess all-cause, cancer, and cardiovascular mortality.

 

Conclusions:

The individuals with CWP are prone to excess mortality. UK Biobank outcomes significantly decrease uncertainty around the magnitude of excess risk and are constant with the excess being defined by adverse lifestyle factors, which could be targeted during the treatment of such patients.

Source:

Ann Rheum Dis. 2017 Jul 21

Link to the source:

https://www.ncbi.nlm.nih.gov/pubmed/28733474

Original title of article:

Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and meta-analysis.

Authors:

Macfarlane GJ et al.

Exploratory, Epidemiology, Chronic Widespread Pain, Meta-analysis
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