Correlation of neurochemical and imaging markers in migraine via PACAP38 and DTI measures

Primary tabs

Correlation of neurochemical and imaging markers in migraine via PACAP38 and DTI measures
Key Take-Away: 

Many previous studies have put some insights into the fact that pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) plays a prominent role in the activation of the trigeminovascular system. This study revealed a significant correlation between diffusion parameters of the white matter and interictal plasma PACAP38-LI in patients with migraine in the occipital white matter.


To investigate if interictal plasma pituitary adenylate cyclase-activating peptide 38-like immunoreactivity (PACAP38-LI) depicts a correlation with microstructural integrity of the white matter in migraine.



The Interictal plasma PACAP38-LI was determined by radioimmunoassay in 26 patients with migraine (24 women) who underwent diffusion tensor imaging afterwards using a 1.5-Tesla magnetic resonance scanner. Data were analysed via tract-based spatial statistics contained in the FMRIB's Software Library.



Interictal plasma PACAP38-LI depicted significant correlation with mean diffusivity (p < 0.0179) mainly in the bilateral occipital white matter spreading into the parietal and temporal white matter. The Axial and radial diffusivity showed a positive correlation with interictal PACAP38-LI in the left optic radiation and left posterior corpus callosum. The fractional anisotropy did not correspond significantly with PACAP38-LI. The disease duration was considered as nuisance regressor in the model and PACAP38-LI agreed with axial and mean diffusivity in the left thalamus.



The authors reported a link between PACAP38, a pathobiologically crucial neurochemical biomarker, and imaging markers of the disease that may bolster future research into the role of PACAP38 in migraine.




Original title of article:

Correlation of neurochemical and imaging markers in migraine: PACAP38 and DTI measures


Vereb D et al.


Diagnostic, Migraine, White matter, Fractional anisotropy, Tract-based spatial statistics
Log in or register to post comments