Correlation of neurochemical and imaging markers in migraine via PACAP38 and DTI measures

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Correlation of neurochemical and imaging markers in migraine via PACAP38 and DTI measures
Key Take-Away: 

Many previous studies have put some insights into the fact that pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) plays a prominent role in the activation of the trigeminovascular system. This study revealed a significant correlation between diffusion parameters of the white matter and interictal plasma PACAP38-LI in patients with migraine in the occipital white matter.

Introduction:

To investigate if interictal plasma pituitary adenylate cyclase-activating peptide 38-like immunoreactivity (PACAP38-LI) depicts a correlation with microstructural integrity of the white matter in migraine.

 

Methods:

The Interictal plasma PACAP38-LI was determined by radioimmunoassay in 26 patients with migraine (24 women) who underwent diffusion tensor imaging afterwards using a 1.5-Tesla magnetic resonance scanner. Data were analysed via tract-based spatial statistics contained in the FMRIB's Software Library.

 

Results:

Interictal plasma PACAP38-LI depicted significant correlation with mean diffusivity (p < 0.0179) mainly in the bilateral occipital white matter spreading into the parietal and temporal white matter. The Axial and radial diffusivity showed a positive correlation with interictal PACAP38-LI in the left optic radiation and left posterior corpus callosum. The fractional anisotropy did not correspond significantly with PACAP38-LI. The disease duration was considered as nuisance regressor in the model and PACAP38-LI agreed with axial and mean diffusivity in the left thalamus.

 

Conclusions:

The authors reported a link between PACAP38, a pathobiologically crucial neurochemical biomarker, and imaging markers of the disease that may bolster future research into the role of PACAP38 in migraine.

Source

Neurology

Link:

https://www.ncbi.nlm.nih.gov/pubmed/30135251

Original title of article:

Correlation of neurochemical and imaging markers in migraine: PACAP38 and DTI measures

Authors:

Vereb D et al.

 

Diagnostic, Migraine, White matter, Fractional anisotropy, Tract-based spatial statistics
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