Risk of knee OA with obesity, sarcopenic obesity and sarcopenia

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Risk of knee OA with obesity, sarcopenic obesity and sarcopenia
Key Take-Away: 

One of the major risk factors of knee OA is obesity, the following study results we found body composition and sarcopenic obesity to be associated with the risk of knee OA.

As defined by anthropometric measures, obesity is a well‐recognised risk factor for knee osteoarthritis (OA) however, the information concerning knee OA risk and body composition (fat and muscle mass) is relatively insufficient. The analysis investigated the longitudinal connection of body composition divisions based on muscle mass and fat with knee OA.



The Multicenter Osteoarthritis (MOST) Study, a longitudinal cohort of people with or at knee OA risk was analyzed to select the participants. The chosen subjects were classified into four classes; sarcopenic, obese, non‐sarcopenic non‐obese, and sarcopenic obese. The binomial regression with robust variance estimation, adjusting for potential confounders was used to measure the association of risk of incident radiographic OA with the baseline body composition classes at the period of five years.



A considerably increased risk of incident radiographic knee OA was observed between the sarcopenic obese and obese women. The patients with sarcopenia alone exhibited no connection with knee OA risk.



This large longitudinal cohort demonstrated a link between knee OA risk and obesity/sarcopenic obesity. Therefore, the weight loss strategies should be focused on obesity and sarcopenic obesity to reduce the knee OA risk.


Arthritis Rheumatol

Link to the source:


Original title of article:

Risk of knee OA with obesity, sarcopenic obesity and sarcopenia.


Devyani Misra et al.

Exploratory, Knee Osteoarthritis, Multicenter Osteoarthritis Study
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