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To assess the impact of combination therapy– azithromycin with fluticasone propionate aerosol inhalation on immune function in children suffering from mycoplasma pneumoniae (MP)-induced chronic cough.
The use of azithromycin with fluticasone inhaled aerosol therapy is a promising, comprehensive approach compared to antibiotics alone, offering both antimicrobial and anti-inflammatory effects for children with long-term cough from mycoplasma pneumoniae infection.
To assess the impact of combination therapy– azithromycin with fluticasone propionate aerosol inhalation on immune function in children suffering from mycoplasma pneumoniae (MP)-induced chronic cough.
A total of 110 children with chronic cough caused by MP infection were considered and divided into two groups: 58 children in the control group received azithromycin dry suspension, while 52 children in the intervention group received azithromycin dry suspension and fluticasone inhalation aerosol combo. Parameters such as lung function, inflammatory markers, immune parameters, lab results, adverse reactions, and overall therapeutic effectiveness were compared between the two groups.
Both groups showed improvements in pulmonary function tests (forced expiratory volume in 1 second, forced vital capacity, and peak expiratory flow) post-treatment compared to baseline, with the intervention group exhibiting more significant improvements (all P < 0.05). Levels of interleukins (IL-17, IL-6, and IL-10) decreased in both groups after treatment, with the intervention group demonstrating greater reductions (all P < 0.05).
Antibodies (IgG, IgA and IgM), inflammatory markers (C-reactive protein [CRP] and erythrocyte sedimentation rate [ESR]), and a specific marker for bacterial infections (procalcitonin levels) were lower in both groups after treatment, with the intervention group showing the most pronounced decreases (all P < 0.05). The intervention group also had a higher rate of treatment success (P < 0.05). The incidence of adverse reactions did not vary significantly amongst the study groups.
Azithromycin dry suspension plus fluticasone propionate aerosol inhalation in children with chronic cough caused by MP infection helps to reduce inflammatory markers, enhance immune function, and improve efficacy outcomes.
European Journal of Pediatrics
Effect of Azithromycin combined with Fluticasone propionate aerosol inhalation on immune function in children with chronic cough caused by Mycoplasma pneumoniae infection
Xin Yang et al.
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