Ziziphus jujube vs. PEG for functional constipation :- Medznat
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Ziziphus jujuba syrup outperforms PEG in relieving pediatric constipation

Pediatric constipation Pediatric constipation
Pediatric constipation Pediatric constipation

What's new?

Ziziphus jujuba syrup is effective and safe to treat pediatric functional constipation with better outcomes than polyethylene glycol.

In a randomized clinical trial led by Fatemeh Keihanian et al., Ziziphus jujuba syrup (ZS), a traditional herbal remedy, appeared to be a safe and effective intervention for functional constipation in children, potentially offering a promising alternative to polyethylene glycol (PEG). The study, conducted in Iran, involved 90 children aged 2–10 with diagnosed functional constipation. Volunteers were randomized to:

  • PEG group (1–5 cc/kg/day, average dose 0.2–1 g/kg)
  • ZS group (1–5 cc/kg/day, average dose 5–25 mg/kg)

The enrolled children were monitored for 3 months. Follow-ups were carried out every 2 weeks during the first 30 days and monthly for the next 2 months. Liver and kidney function tests, along with blood sugar levels, were conducted at both the beginning and end of the trial.

Key results:

  • Therapeutic response: The ZS group showed a significantly greater improvement in therapeutic response scores when compared to the PEG group (P < 0.05).
  • Encopresis: The average number of encopresis episodes dropped markedly in the ZS group as opposed to the PEG group (P < 0.05).
  • Pain Management: Visual analog scale (VAS) pain scores also reduced substantially in the ZS group (P < 0.05).
  • Defecation Frequency & Medication Adherence: Those in the ZS group experienced substantially improved defecation frequency and better medication adherence than those in the PEG group (P < 0.05).
  • Safety Findings: No adverse events or changes in liver or kidney function were reported in the ZS group. In contrast, a few cases in the PEG group experienced mild, self-limiting adverse effects.

With no significant liver or kidney damage and notable improvements in symptoms, ZS shows promise as an effective, low-cost, and well-tolerated alternative for tackling pediatric functional constipation. However, additional research is warranted to determine its long-term safety.

Source:

Scientific Reports

Article:

Comparison of Ziziphus jujube Mill. Syrup versus polyethylene glycol in children with functional constipation: a randomized clinical trial

Authors:

Fatemeh Keihanian et al.

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