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Low vitamin D levels are consistently linked to RLS, while low folate levels are specific to pregnant women with RLS. Supplementation with vitamins C, E, and B6 may help improve symptoms, suggesting a role for vitamin deficiencies in RLS pathogenesis.
A systematic review and meta-analysis issued in "Plos One" has revealed intriguing connections between vitamin levels and restless leg syndrome (RLS), suggesting that certain deficiencies may play a role in the condition’s development while specific supplements could offer relief.
This study scrutinized the potential role of vitamins in the pathogenesis and treatment of RLS through a comprehensive search of PubMed, Cochrane, Embase, and Web of Science databases.
Analyzing data from 59 studies, researchers found that RLS patients had considerably lower vitamin D levels, with more severe cases linked to greater deficiencies. Pregnant women with RLS also exhibited lower folate levels as opposed to their non-RLS counterparts, but this pattern was absent in non-pregnant individuals.
Interestingly, vitamin B12 and B1 levels illustrated no association with RLS, challenging prior assumptions. When it comes to treatment, oral vitamin B6 remarkably improved symptoms in primary RLS, while vitamin D supplementation did not show a clear benefit. For hemodialysis-associated RLS, vitamins C, E, and their combination yielded substantial symptom relief— with vitamin C proving as efficient as the standard drug pramipexole.
These findings suggest that addressing vitamin deficiencies, particularly vitamin D and folate in pregnancy, could be key in understanding RLS. Additionally, vitamins B6, C, and E may serve as promising alternatives or adjuncts to conventional RLS treatments.
Plos One
Role of vitamins in the pathogenesis and treatment of restless leg syndrome: A systematic review and meta-analysis
Xiao-Min Xu et al.
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